ALDH4A1

Description		aldehyde dehydrogenase 4 family member A1
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	L-glutamate Gamma-semialdehyde Dehydrogenase Activity Aldehyde Dehydrogenase (NAD+) Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding
	Biological Process	Proline Metabolic Process L-proline Catabolic Process L-proline Catabolic Process To L-glutamate Trans-4-hydroxy-L-proline Catabolic Process
Pathways		Glyoxylate metabolism and glycine degradation Proline catabolism
Drugs		NADH
Diseases		Hyperprolinemia (HP)
GWAS		Alzheimer's disease (survival time) ( 25649651) Anorexia nervosa ( 23568457) Metabolite levels ( 23823483)
Novel Interacting Genes		3 novel interacting genes: APP ARG1 OGT
Interacting Genes		3 interacting genes: APP ARG1 OGT
Entrez ID		8659
HPRD ID		06009
Ensembl ID		ENSG00000159423
Uniprot IDs		A0A024RAC7 P30038
PDB IDs		3V9G 3V9H 3V9I 4OE5 8RKQ 8RKR
Enriched GO Terms of Interacting Partners?		Regulation Of Glycolytic Process Regulation Of ATP Metabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Synapse Assembly Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Gene Expression Endosome To Plasma Membrane Transport Vesicle Hemopoiesis Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Endothelin Production Growth Cone Filopodium Defense Response Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Neutrophil Mediated Killing Of Fungus Arginase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amidines Protein O-acetylglucosaminyltransferase Activity Regulation Of Cell Junction Assembly Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Cellular Response To Norepinephrine Stimulus Regulation Of Programmed Cell Death Astrocyte Activation Involved In Immune Response Negative Regulation Of Cell Communication Low-density Lipoprotein Particle Mediated Signaling Negative Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of Killing Of Cells Of Another Organism Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding
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