UNC5C and NTN1

Number of citations of the paper that reports this interaction (PubMedID 12810718)
0

Data Source:
HPRD (in vitro)

		UNC5C	NTN1
Description		unc-5 netrin receptor C	netrin 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Lamellipodium Filopodium Axon Dendrite Growth Cone Cell Projection Neuron Projection Neuronal Cell Body Synapse	Extracellular Region Basement Membrane Nucleoplasm Cytoplasm Cytosol Actin Cytoskeleton Synapse Glutamatergic Synapse
	Molecular Function	Netrin Receptor Activity Netrin Receptor Activity Involved In Chemorepulsion Protein Binding Tubulin Binding Protein Kinase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Apoptotic Process Signal Transduction Axon Guidance Brain Development Regulation Of Cell Migration Anterior/posterior Axon Guidance Ectopic Germ Cell Programmed Cell Death Netrin-activated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Developmental Process Chemorepulsion Of Axon Dorsal Root Ganglion Development Positive Regulation Of Reproductive Process Regulation Of Neuron Migration	Neuron Migration Regulation Of Transcription By RNA Polymerase II Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Axonogenesis Axon Guidance Cell Population Proliferation Glial Cell Proliferation Regulation Of Cell Migration Negative Regulation Of Axon Extension Mammary Gland Development Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Positive Regulation Of Glial Cell Proliferation Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Motor Neuron Migration Cell-cell Adhesion Regulation Of Glial Cell Migration Positive Regulation Of Cell Motility
Pathways		Netrin mediated repulsion signals Netrin mediated repulsion signals	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alcohol dependence symptom count ( 29460428) Blood protein levels ( 30072576) Cerebrospinal P-tau181p levels ( 20932310) Coronary artery disease ( 29212778) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Major depressive disorder ( 29317602) Maximum stenosis ( 32469969) Myocardial infarction ( 33532862) Obesity-related traits ( 23251661) Obsessive-compulsive symptoms ( 26859814) Optic nerve measurement (cup-to-disc ratio) ( 20395239) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Residual cognition ( 28441426) Sum of carotid plaque area ( 32469969) Sum of stenosis ( 32469969) Type 2 diabetes ( 31049640)	Appendicular lean mass ( 33097823) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Breast cancer (prognosis) ( 23319801) Cortex volume ( 31530798) Feeling hurt ( 29500382) Heel bone mineral density ( 28869591 30598549) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280 33898419) Orofacial clefts ( 33137956) Percentage gas trapping ( 26030696) Rostral middle frontal gyrus volume ( 31530798) Total grey matter volume ( 31530798)
Interacting Genes		2 interacting genes: DAPK1 NTN1	5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C
Entrez ID		8633	9423
HPRD ID		04678	03368
Ensembl ID		ENSG00000182168	ENSG00000065320
Uniprot IDs		A8K385 O95185	O95631
PDB IDs			4URT 6FKQ 7NDG 7NE0 7NE1
Enriched GO Terms of Interacting Partners?		DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of NMDA Receptor Activity Actin Cytoskeleton Cdc42 Protein Signal Transduction Cellular Response To Hydroperoxide Defense Response To Tumor Cell Glutamatergic Synapse Chemorepulsion Of Axon Substrate-dependent Cell Migration, Cell Extension Anterior/posterior Axon Guidance Mammary Gland Duct Morphogenesis Motor Neuron Migration Apoptotic Process Calcium/calmodulin-dependent Protein Kinase Activity Response To Hydroperoxide Regulation Of Neurotransmitter Receptor Activity Syntaxin-1 Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Glial Cell Migration Cell Death Programmed Cell Death Regulation Of Response To Tumor Cell Nucleus Localization Glial Cell Proliferation Negative Regulation Of Axon Extension Nuclear Migration Regulation Of Signaling Receptor Activity Organelle Mammary Gland Development Positive Regulation Of Axon Extension Regulation Of Glial Cell Proliferation Negative Chemotaxis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Axonogenesis Inner Ear Morphogenesis Positive Regulation Of Gliogenesis Rho Protein Signal Transduction	Anterior/posterior Axon Guidance Neuron Projection Guidance Axon Guidance Netrin Receptor Activity Neuron Projection Development Netrin-activated Signaling Pathway Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Modulation Of Chemical Synaptic Transmission Netrin Receptor Activity Involved In Chemorepulsion Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Cell Surface Negative Regulation Of Neuron Projection Development Growth Cone Neuron Migration Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Neuron Projection Membrane Negative Regulation Of Cell Projection Organization Positive Regulation Of Chronic Inflammatory Response G Protein-coupled Adenosine Receptor Activity Plasma Membrane Cell Death Apoptotic Process Programmed Cell Death Dorsal Root Ganglion Development Relaxation Of Vascular Associated Smooth Muscle Chemorepulsion Of Axon Positive Regulation Of CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Dendrite Development Regulation Of Chronic Inflammatory Response G Protein-coupled Adenosine Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Regulation Of CGMP-mediated Signaling Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Collateral Sprouting Co-receptor Binding Negative Regulation Of Axon Regeneration BMP Receptor Binding Negative Regulation Of Neuron Projection Regeneration Trans-synaptic Signaling, Modulating Synaptic Transmission Neuron Projection Positive Regulation Of Mast Cell Degranulation Plasma Membrane Protein Complex Ganglion Development Secretion By Cell Positive Regulation Of Adenylate Cyclase Activity
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