NTN1

Description		netrin 1
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Nucleoplasm Cytoplasm Cytosol Actin Cytoskeleton Synapse Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Neuron Migration Regulation Of Transcription By RNA Polymerase II Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Axonogenesis Axon Guidance Cell Population Proliferation Glial Cell Proliferation Regulation Of Cell Migration Negative Regulation Of Axon Extension Mammary Gland Development Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Positive Regulation Of Glial Cell Proliferation Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Motor Neuron Migration Cell-cell Adhesion Regulation Of Glial Cell Migration Positive Regulation Of Cell Motility
Pathways		Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Breast cancer (prognosis) ( 23319801) Cortex volume ( 31530798) Feeling hurt ( 29500382) Heel bone mineral density ( 28869591 30598549) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280 33898419) Orofacial clefts ( 33137956) Percentage gas trapping ( 26030696) Rostral middle frontal gyrus volume ( 31530798) Total grey matter volume ( 31530798)
Novel Interacting Genes		5 novel interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C
Interacting Genes		5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C
Entrez ID		9423
HPRD ID		03368
Ensembl ID		ENSG00000065320
Uniprot IDs		O95631
PDB IDs		4URT 6FKQ 7NDG 7NE0 7NE1
Enriched GO Terms of Interacting Partners?		Anterior/posterior Axon Guidance Neuron Projection Guidance Axon Guidance Netrin Receptor Activity Neuron Projection Development Netrin-activated Signaling Pathway Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Positive Regulation Of Chronic Inflammatory Response To Non-antigenic Stimulus Modulation Of Chemical Synaptic Transmission Netrin Receptor Activity Involved In Chemorepulsion Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Cell Surface Negative Regulation Of Neuron Projection Development Growth Cone Neuron Migration Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Neuron Projection Membrane Negative Regulation Of Cell Projection Organization Positive Regulation Of Chronic Inflammatory Response G Protein-coupled Adenosine Receptor Activity Plasma Membrane Cell Death Apoptotic Process Programmed Cell Death Dorsal Root Ganglion Development Relaxation Of Vascular Associated Smooth Muscle Chemorepulsion Of Axon Positive Regulation Of CGMP-mediated Signaling Relaxation Of Smooth Muscle Negative Regulation Of Dendrite Development Regulation Of Chronic Inflammatory Response G Protein-coupled Adenosine Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Regulation Of CGMP-mediated Signaling Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Collateral Sprouting Co-receptor Binding Negative Regulation Of Axon Regeneration BMP Receptor Binding Negative Regulation Of Neuron Projection Regeneration Trans-synaptic Signaling, Modulating Synaptic Transmission Neuron Projection Positive Regulation Of Mast Cell Degranulation Plasma Membrane Protein Complex Ganglion Development Secretion By Cell Positive Regulation Of Adenylate Cyclase Activity
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