TRIM5 and UBE2V1

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		TRIM5	UBE2V1
Description		tripartite motif containing 5	ubiquitin conjugating enzyme E2 V1
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Omegasome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Protein-containing Complex Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Activation Of Innate Immune Response Immune System Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process	Protein Polyubiquitination Regulation Of DNA Repair Postreplication Repair Regulation Of DNA-templated Transcription Cell Differentiation Error-free Postreplication DNA Repair Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction
Pathways		Interferon gamma signaling	NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PINK1-PRKN Mediated Mitophagy CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 29212778 33020668) DNA methylation (variation) ( 23725790) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Myocardial infarction ( 33532862) Platelet count ( 32888494 29403010) Serum alkaline phosphatase levels ( 33339817 29403010 33547301) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)
Interacting Genes		49 interacting genes: BTBD1 BTBD2 CFTR DSCR9 EHHADH EWSR1 ITSN1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1	49 interacting genes: ARIH2 BIRC2 BIRC3 BIRC8 CTAG1A CTAG1B DAZAP2 DTX3 DZIP3 FAM168A KITLG MAP3K1 MID1 MKRN3 PELI1 PELI3 PRKN RC3H1 RC3H2 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 SHISA4 SMURF1 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM21 TRIM25 TRIM32 TRIM39 TRIM5 TRIM8 UBC UBE2N UBE3B UBOX5 UBQLN1 UBQLN2 XBP1 XIAP ZNRF1 ZNRF2
Entrez ID		85363	7335
HPRD ID		07004	04294
Ensembl ID		ENSG00000132256	ENSG00000244687
Uniprot IDs		A0A804HHS7 Q9C035	G3V2F7 Q13404
PDB IDs		2ECV 2YRG	2A4D 2C2V 2HLW 6D6I
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Metabolic Process Proteolysis Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Deubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process UBC13-MMS2 Complex Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Ubiquitin Conjugating Enzyme Complex Cysteine-type Peptidase Activity Transferase Activity Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Nucleus Positive Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Free Ubiquitin Chain Polymerization Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein K11-linked Deubiquitination Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Error-free Postreplication DNA Repair Positive Regulation Of Protein Modification Process Ubiquitin Binding Catabolic Process Positive Regulation Of Protein Ubiquitination Response To Virus Suppression Of Viral Release By Host Cytosol	Ubiquitin Protein Ligase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein K63-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Regulation Of Immune Response Regulation Of Protein Ubiquitination Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Ubiquitination Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Metal Ion Binding Regulation Of Innate Immune Response ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Suppression Of Viral Release By Host Protein Autoubiquitination Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of ERAD Pathway Regulation Of Protein Modification Process Positive Regulation Of Immune Response
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