UBE2V1 and UBOX5

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		UBE2V1	UBOX5
Description		ubiquitin conjugating enzyme E2 V1	U-box domain containing 5
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Protein-containing Complex Extracellular Exosome	Nucleus Nucleoplasm Focal Adhesion Nuclear Body
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Regulation Of DNA Repair Postreplication Repair Regulation Of DNA-templated Transcription Cell Differentiation Error-free Postreplication DNA Repair Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction	Protein Polyubiquitination Protein Ubiquitination
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PINK1-PRKN Mediated Mitophagy CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Household income ( 31844048) Household income (MTAG) ( 31844048) Night sleep phenotypes ( 27126917)
Interacting Genes		49 interacting genes: ARIH2 BIRC2 BIRC3 BIRC8 CTAG1A CTAG1B DAZAP2 DTX3 DZIP3 FAM168A KITLG MAP3K1 MID1 MKRN3 PELI1 PELI3 PRKN RC3H1 RC3H2 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 SHISA4 SMURF1 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM21 TRIM25 TRIM32 TRIM39 TRIM5 TRIM8 UBC UBE2N UBE3B UBOX5 UBQLN1 UBQLN2 XBP1 XIAP ZNRF1 ZNRF2	19 interacting genes: MLH1 NEDD4 TRAF6 TRAIP TRIM23 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2L3 UBE2V1 UBE2W USP2 VCP
Entrez ID		7335	22888
HPRD ID		04294	15605
Ensembl ID		ENSG00000244687	ENSG00000185019
Uniprot IDs		G3V2F7 Q13404	O94941
PDB IDs		2A4D 2C2V 2HLW 6D6I
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein K63-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Regulation Of Immune Response Regulation Of Protein Ubiquitination Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Ubiquitination Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Metal Ion Binding Regulation Of Innate Immune Response ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Suppression Of Viral Release By Host Protein Autoubiquitination Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of ERAD Pathway Regulation Of Protein Modification Process Positive Regulation Of Immune Response	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification Process Protein K11-linked Ubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Transferase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Monoubiquitination Macromolecule Metabolic Process Nucleotide Binding Macromolecule Catabolic Process ATP Binding Protein K63-linked Ubiquitination Proteolysis Nucleus DNA Damage Response Ubiquitin Protein Ligase Activity Catabolic Process Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Ubiquitin Ligase Complex ISG15 Transferase Activity DNA Repair Positive Regulation Of Protein Metabolic Process Ubiquitin Protein Ligase Binding ISG15-protein Conjugation Cellular Response To Stress Nucleoplasm Protein-DNA Covalent Cross-linking Repair Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Modification Process Negative Regulation Of Biosynthetic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Protein Autoubiquitination Cellular Response To Misfolded Protein Response To Misfolded Protein DNA Metabolic Process Regulation Of Metabolic Process Protein-containing Complex Ubiquitin-ubiquitin Ligase Activity
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