UBE2V1 and PELI3

Number of citations of the paper that reports this interaction (PubMedID 23892723)
0

Data Source:
BioGRID (pull down)

		UBE2V1	PELI3
Description		ubiquitin conjugating enzyme E2 V1	pellino E3 ubiquitin protein ligase family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Protein-containing Complex Extracellular Exosome	Cytosol
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Regulation Of DNA Repair Postreplication Repair Regulation Of DNA-templated Transcription Cell Differentiation Error-free Postreplication DNA Repair Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Protein K63-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Intracellular Signal Transduction	Protein Polyubiquitination Immune System Process Regulation Of Toll Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Ubiquitination Innate Immune Response Protein K63-linked Ubiquitination Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 PINK1-PRKN Mediated Mitophagy CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy SARS-CoV-2 activates/modulates innate and adaptive immune responses TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation	Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Interacting Genes		49 interacting genes: ARIH2 BIRC2 BIRC3 BIRC8 CTAG1A CTAG1B DAZAP2 DTX3 DZIP3 FAM168A KITLG MAP3K1 MID1 MKRN3 PELI1 PELI3 PRKN RC3H1 RC3H2 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 SHISA4 SMURF1 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM21 TRIM25 TRIM32 TRIM39 TRIM5 TRIM8 UBC UBE2N UBE3B UBOX5 UBQLN1 UBQLN2 XBP1 XIAP ZNRF1 ZNRF2	12 interacting genes: APP IRAK1 IRAK2 IRAK4 MAP3K14 MAP3K7 RIPK2 TRAF6 TRIM55 TRIM63 UBE2N UBE2V1
Entrez ID		7335	246330
HPRD ID		04294	17535
Ensembl ID		ENSG00000244687	ENSG00000174516
Uniprot IDs		G3V2F7 Q13404	Q8N2H9
PDB IDs		2A4D 2C2V 2HLW 6D6I
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein K63-linked Ubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Post-translational Protein Modification Regulation Of Immune Response Regulation Of Protein Ubiquitination Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Ubiquitination Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Metal Ion Binding Regulation Of Innate Immune Response ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Cytoplasm Suppression Of Viral Release By Host Protein Autoubiquitination Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of ERAD Pathway Regulation Of Protein Modification Process Positive Regulation Of Immune Response	MyD88-dependent Toll-like Receptor Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Pattern Recognition Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Interleukin-1-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Defense Response Response To Interleukin-1 Interleukin-33-mediated Signaling Pathway Non-canonical NF-kappaB Signal Transduction Lipopolysaccharide-mediated Signaling Pathway Response To Other Organism Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune System Process Intracellular Signaling Cassette Response To External Biotic Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Immune Response-activating Signaling Pathway Response To Stress Innate Immune Response Endolysosomal Toll-like Receptor Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Activation Of Immune Response Defense Response To Symbiont Regulation Of Innate Immune Response Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Defense Response To Other Organism Positive Regulation Of Defense Response Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Toll Signaling Pathway Positive Regulation Of Protein K63-linked Ubiquitination Response To Cytokine Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Response To Peptide Regulation Of Immune Response Positive Regulation Of Immune System Process
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