GLYR1 and GEMIN4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GLYR1	GEMIN4
Description		glyoxylate reductase 1 homolog	gem nuclear organelle associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleosome Nucleus Nucleoplasm Chromosome Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Cajal Bodies
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Nucleosome Binding Histone Binding NADP Binding NAD Binding Chromatin-protein Adaptor Activity	Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Transcription Initiation-coupled Chromatin Remodeling Transcription Elongation-coupled Chromatin Remodeling	Spliceosomal SnRNP Assembly RRNA Processing MRNA Processing RNA Splicing
Pathways			snRNP Assembly SARS-CoV-2 modulates host translation machinery
Drugs
Diseases
GWAS		Cancer ( 29299148) Night sleep phenotypes ( 27126917)	Prostate cancer ( 23535732)
Interacting Genes		15 interacting genes: ARL16 CCNC CDKN2D CFAP206 CLIC3 EIF1AD FHL2 FXR1 GEMIN4 GLIS2 H3-4 H3C1 KDM1A NSD3 NTMT1	57 interacting genes: AGO2 ALPP CALCOCO2 CCDC185 CCT3 CDC20B CERCAM CFP DDX20 DHX9 DMPK FBXL12 FLAD1 GEMIN5 GLYR1 HR KANK2 KARS1 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP9-2 LGALS1 LGALS3 LY86 MORC4 NPPB NUFIP1 PIAS3 PSMB1 PTCD1 PTEN RAD51D RN7SL1 RNASE2 RNF10 RNU1-1 RNU2-1 S1PR4 SNRPB SNRPD1 SNRPD2 SPG21 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TAP1 TOP1 UFC1 USP15 USP2 ZNF326 ZNF35
Entrez ID		84656	50628
HPRD ID		17625	07370
Ensembl ID		ENSG00000140632	ENSG00000179409
Uniprot IDs		Q49A26 Q9NZ78	I3L2C7 P57678 Q8WUM5 Q9HC39
PDB IDs		2UYY 4GUR 4GUS 4GUT 4GUU 4HSU 6R1U 6R25
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Ribonucleoprotein Complex Binding Chromatin Remodeling Chromatin Organization N-terminal Protein N-methyltransferase Activity N-terminal Protein Amino Acid Methylation Histone Methyltransferase Activity N-terminal Peptidyl-serine Dimethylation N-terminal Peptidyl-proline Dimethylation N-terminal Peptidyl-serine Trimethylation N-terminal Peptidyl-glycine Methylation Histone H3K4 Dimethyltransferase Activity Histone H3K27 Dimethyltransferase Activity A Axonemal Microtubule Atrial Cardiac Muscle Cell Development Protein-disulfide Reductase (glutathione) Activity Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Cyclin D2-CDK4 Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Translational Initiation Chromosome Structural Constituent Of Chromatin Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone H3K27 Trimethyltransferase Activity	SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly U2 SnRNP 7-methylguanosine Cap Hypermethylation RNA Processing U4 SnRNP Methylosome Intermediate Filament Small Nuclear Ribonucleoprotein Complex RNA Splicing U1 SnRNP Tertiary Granule U5 SnRNP Presynaptic Dense Core Vesicle Exocytosis U2-type Prespliceosome Assembly U12-type Spliceosomal Complex MRNA Processing Perichromatin Fibrils U2-type Spliceosomal Complex RNA Polymerase II Complex Binding U2-type Catalytic Step 2 Spliceosome RNA Metabolic Process Positive Regulation Of Dendritic Cell Differentiation PICln-Sm Protein Complex Neuronal Dense Core Vesicle Exocytosis U1 SnRNP Binding Neutrophil Degranulation Transcription Elongation-coupled Chromatin Remodeling Keratin Filament RISC-loading Complex Dense Core Granule Exocytosis U4/U6 X U5 Tri-snRNP Complex RNA Binding Anaphase-promoting Complex Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter RISC Complex Assembly MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly SiRNA Binding SMN Complex U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Cytosol Locomotor Rhythm Ubiquitin Ligase Activator Activity Gemini Of Cajal Bodies Protein Binding Ribonucleoside Triphosphate Phosphatase Activity MRNA Metabolic Process
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