SPINK7 and MT1H

Number of citations of the paper that reports this interaction (PubMedID 12970870)
34

Data Source:
HPRD (two hybrid)

		SPINK7	MT1H
Description		serine peptidase inhibitor Kazal type 7	metallothionein 1H
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Cytoplasm
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Inflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response	Intracellular Zinc Ion Homeostasis Detoxification Of Copper Ion Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion
Pathways			Metallothioneins bind metals
Drugs			Silver
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Experiencing mood swings ( 29500382)	Gambling ( 22780124)
Interacting Genes		9 interacting genes: EPB42 FTL GALNT10 HBA1 MRPS12 MT1G MT1H MT2A RABL6	4 interacting genes: PRKAR2B RNF181 SERPINB5 SPINK7
Entrez ID		84651	4496
HPRD ID		16850	01128
Ensembl ID		ENSG00000145879	ENSG00000205358
Uniprot IDs		P58062	A0A140VJP7 P80294
PDB IDs		2LEO
Enriched GO Terms of Interacting Partners?		Detoxification Of Copper Ion Cellular Response To Cadmium Ion Cellular Response To Zinc Ion Cellular Response To Copper Ion Intracellular Zinc Ion Homeostasis Response To Copper Ion Inorganic Ion Homeostasis Response To Cadmium Ion Response To Zinc Ion Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Chemical Homeostasis Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Cellular Response To Metal Ion Intracellular Chemical Homeostasis Negative Regulation Of Growth Cellular Homeostasis Homeostatic Process Response To Metal Ion Ferritin Complex Iron Ion Binding Haptoglobin Binding Cellular Response To Erythropoietin Nitric Oxide Transport Response To Erythropoietin Regulation Of Growth Ankyrin-1 Complex Protein-glutamine Gamma-glutamyltransferase Activity Ferric Iron Binding Cellular Response To Interleukin-3 Metal Ion Binding Monocyte Activation Hemoglobin Metabolic Process Haptoglobin-hemoglobin Complex Autolysosome Hemoglobin Complex Oxygen Carrier Activity Polypeptide N-acetylgalactosaminyltransferase Activity Carbon Dioxide Transport Intracellular Copper Ion Homeostasis Oxygen Transport Erythrocyte Maturation Hydrogen Peroxide Catabolic Process Endocytic Vesicle Lumen Monocyte Differentiation Copper Ion Homeostasis Ferrous Iron Binding Multicellular Organismal-level Iron Ion Homeostasis One-carbon Compound Transport	Serine-type Endopeptidase Inhibitor Activity Response To Antipsychotic Drug Prostate Gland Morphogenesis CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity
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