SPINK7 and FTL

Number of citations of the paper that reports this interaction (PubMedID 12646258)
0

Data Source:
BioGRID (two hybrid)

		SPINK7	FTL
Description		serine peptidase inhibitor Kazal type 7	ferritin light chain
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Cytoplasm Lysosome Autophagosome Cytosol Membrane Cytoplasmic Vesicle Azurophil Granule Lumen Autolysosome Extracellular Exosome Ferritin Complex
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Inflammatory Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response	Iron Ion Transport Intracellular Iron Ion Homeostasis
Pathways			Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport
Drugs			Iron Dextran Protoporphyrin Ferric pyrophosphate Sodium ferric gluconate complex Ferric pyrophosphate citrate
Diseases			Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Experiencing mood swings ( 29500382)
Interacting Genes		9 interacting genes: EPB42 FTL GALNT10 HBA1 MRPS12 MT1G MT1H MT2A RABL6	31 interacting genes: ACO1 CLEC4G FTH1 GADD45A GLP1R GRB2 HTT IGDCC3 KNG1 KPNA3 MAP3K12 MEOX2 MPHOSPH6 MTNR1B MYOC MYOG NTAQ1 PALS2 PIK3CA PPP1CC PTN RAP2A SDCBP SLC13A1 SMAD9 SPINK7 TAF10 UBC USHBP1 VKORC1 ZDHHC17
Entrez ID		84651	2512
HPRD ID		16850	00616
Ensembl ID		ENSG00000145879	ENSG00000087086
Uniprot IDs		P58062	A0A384MDR3 P02792
PDB IDs		2LEO	2FFX 2FG4 2FG8 3KXU 4V6B 5LG8 6TR9 6TS0 6TS1 6TSA 6TSF 6TSJ 6WX6
Enriched GO Terms of Interacting Partners?		Detoxification Of Copper Ion Cellular Response To Cadmium Ion Cellular Response To Zinc Ion Cellular Response To Copper Ion Intracellular Zinc Ion Homeostasis Response To Copper Ion Inorganic Ion Homeostasis Response To Cadmium Ion Response To Zinc Ion Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Chemical Homeostasis Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Cellular Response To Metal Ion Intracellular Chemical Homeostasis Negative Regulation Of Growth Cellular Homeostasis Homeostatic Process Response To Metal Ion Ferritin Complex Iron Ion Binding Haptoglobin Binding Cellular Response To Erythropoietin Nitric Oxide Transport Response To Erythropoietin Regulation Of Growth Ankyrin-1 Complex Protein-glutamine Gamma-glutamyltransferase Activity Ferric Iron Binding Cellular Response To Interleukin-3 Metal Ion Binding Monocyte Activation Hemoglobin Metabolic Process Haptoglobin-hemoglobin Complex Autolysosome Hemoglobin Complex Oxygen Carrier Activity Polypeptide N-acetylgalactosaminyltransferase Activity Carbon Dioxide Transport Intracellular Copper Ion Homeostasis Oxygen Transport Erythrocyte Maturation Hydrogen Peroxide Catabolic Process Endocytic Vesicle Lumen Monocyte Differentiation Copper Ion Homeostasis Ferrous Iron Binding Multicellular Organismal-level Iron Ion Homeostasis One-carbon Compound Transport
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