WDR24 and SESN3

Number of citations of the paper that reports this interaction (PubMedID 25263562)
44

Data Source:
BioGRID (pull down)

		WDR24	SESN3
Description		WD repeat domain 24	sestrin 3
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Vacuolar Membrane Cytosol Membrane GATOR2 Complex	Nucleus Cytoplasm TORC2 Complex GATOR2 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor L-leucine Binding
	Biological Process	Cytoplasmic Translation Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Protein Ubiquitination Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Protein K6-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling	Positive Regulation Of Macroautophagy Response To Insulin Cellular Response To Amino Acid Starvation TORC2 Signaling Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Insulin Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Regulation Of Response To Reactive Oxygen Species Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		Amino acids regulate mTORC1	TP53 Regulates Metabolic Genes
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Hip circumference adjusted for BMI ( 34021172) Smoking initiation (ever regular vs never regular) ( 30679032)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Diastolic blood pressure ( 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		5 interacting genes: APPBP2 FBXO7 SESN1 SESN3 SRPK2	5 interacting genes: DSCR9 MIOS NPRL3 WDR24 WDR59
Entrez ID		84219	143686
HPRD ID		15665	09682
Ensembl ID		ENSG00000127580	ENSG00000149212
Uniprot IDs		Q96S15	P58005
PDB IDs		7UHY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macroautophagy L-leucine Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Regulation Of Response To Reactive Oxygen Species GATOR2 Complex Cellular Response To L-leucine Cellular Response To Leucine Starvation Response To L-leucine Positive Regulation Of Autophagy Regulation Of Macroautophagy Regulation Of Response To Oxidative Stress Cellular Response To Glucose Starvation Regulation Of Autophagy Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Stimulus Ubiquitin-like Ligase-substrate Adaptor Activity Positive Regulation Of Catabolic Process Regulation Of TORC1 Signaling Response To Amino Acid Regulation Of TOR Signaling Negative Regulation Of Intracellular Signal Transduction Lewy Body Core Nuclear Speck Organization Cellular Response To Starvation Response To Starvation Regulation Of Neuron Apoptotic Process Cellular Response To Nutrient Levels R-loop Processing TORC2 Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway TORC2 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction Nuclear Body Organization Cul2-RING Ubiquitin Ligase Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Nucleus Positive Regulation Of Mitophagy Protein Modification Process	Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling GATOR2 Complex Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of TOR Signaling Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Positive Regulation Of TORC1 Signaling Lysosomal Membrane Positive Regulation Of TOR Signaling Response To Nutrient Levels Lysosome Vacuolar Membrane Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Oligodendrocyte Progenitor Proliferation Cellular Response To Stress Seh1-associated Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy GATOR1 Complex Central Nervous System Myelin Formation Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Myelin Assembly Regulation Of Autophagy Response To Stress Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Aorta Morphogenesis Protein K6-linked Ubiquitination Ventricular Septum Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Catabolic Process Cellular_component Zinc Ion Binding Oligodendrocyte Differentiation Cardiac Septum Development Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation
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