SESN3

Description		sestrin 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm TORC2 Complex GATOR2 Complex
	Molecular Function	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor L-leucine Binding
	Biological Process	Positive Regulation Of Macroautophagy Response To Insulin Cellular Response To Amino Acid Starvation TORC2 Signaling Cellular Response To Glucose Starvation Glucose Homeostasis Regulation Of Insulin Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Amino Acid Stimulus Cellular Response To L-leucine Regulation Of Response To Reactive Oxygen Species Negative Regulation Of TORC1 Signaling Cellular Response To Leucine Starvation
Pathways		TP53 Regulates Metabolic Genes
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Aspartate aminotransferase levels ( 33547301) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Diastolic blood pressure ( 27841878) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Triglyceride levels x loop diuretics use interaction ( 31806883)
Novel Interacting Genes		5 novel interacting genes: DSCR9 MIOS NPRL3 WDR24 WDR59
Interacting Genes		5 interacting genes: DSCR9 MIOS NPRL3 WDR24 WDR59
Entrez ID		143686
HPRD ID		09682
Ensembl ID		ENSG00000149212
Uniprot IDs		P58005
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling GATOR2 Complex Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of TOR Signaling Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Positive Regulation Of TORC1 Signaling Lysosomal Membrane Positive Regulation Of TOR Signaling Response To Nutrient Levels Lysosome Vacuolar Membrane Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Oligodendrocyte Progenitor Proliferation Cellular Response To Stress Seh1-associated Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Autophagy GATOR1 Complex Central Nervous System Myelin Formation Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Myelin Assembly Regulation Of Autophagy Response To Stress Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Aorta Morphogenesis Protein K6-linked Ubiquitination Ventricular Septum Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Catabolic Process Cellular_component Zinc Ion Binding Oligodendrocyte Differentiation Cardiac Septum Development Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation
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