WDR24

Description		WD repeat domain 24
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Vacuolar Membrane Cytosol Membrane GATOR2 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cytoplasmic Translation Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Protein Ubiquitination Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Localization To Lysosome Protein K6-linked Ubiquitination Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Hip circumference adjusted for BMI ( 34021172) Smoking initiation (ever regular vs never regular) ( 30679032)
Novel Interacting Genes		5 novel interacting genes: APPBP2 FBXO7 SESN1 SESN3 SRPK2
Interacting Genes		5 interacting genes: APPBP2 FBXO7 SESN1 SESN3 SRPK2
Entrez ID		84219
HPRD ID		15665
Ensembl ID		ENSG00000127580
Uniprot IDs		Q96S15
PDB IDs		7UHY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macroautophagy L-leucine Binding Oxidoreductase Activity, Acting On Peroxide As Acceptor Regulation Of Response To Reactive Oxygen Species GATOR2 Complex Cellular Response To L-leucine Cellular Response To Leucine Starvation Response To L-leucine Positive Regulation Of Autophagy Regulation Of Macroautophagy Regulation Of Response To Oxidative Stress Cellular Response To Glucose Starvation Regulation Of Autophagy Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Stimulus Ubiquitin-like Ligase-substrate Adaptor Activity Positive Regulation Of Catabolic Process Regulation Of TORC1 Signaling Response To Amino Acid Regulation Of TOR Signaling Negative Regulation Of Intracellular Signal Transduction Lewy Body Core Nuclear Speck Organization Cellular Response To Starvation Response To Starvation Regulation Of Neuron Apoptotic Process Cellular Response To Nutrient Levels R-loop Processing TORC2 Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway TORC2 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signal Transduction Nuclear Body Organization Cul2-RING Ubiquitin Ligase Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Nucleus Positive Regulation Of Mitophagy Protein Modification Process
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