POMK and THAP1

		POMK	THAP1
Description		protein O-mannose kinase	THAP domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Chromatin Fibrillar Center Nucleus Nucleoplasm PML Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Phosphotransferase Activity, Alcohol Group As Acceptor Carbohydrate Kinase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Protein O-linked Glycosylation Brain Development Learning Or Memory Sensory Perception Of Pain Carbohydrate Phosphorylation Neuromuscular Process	Negative Regulation Of Transcription By RNA Polymerase II Endothelial Cell Proliferation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle
Pathways		DAG1 core M3 glycosylations
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS			Pelvic organ prolapse (moderate/severe) ( 26545240)
Interacting Genes		8 interacting genes: BMPR1B GOLGA7 IER3IP1 MS4A13 OGT TGFBR1 THAP1 UBC	114 interacting genes: ABCF3 ACOT7 AEBP2 AKAP17A AKAP9 AP2B1 APP ARL6IP4 BAG5 BEND7 BMS1P1 BYSL C1orf216 C1orf35 CDC37 CDKN2D CHD2 CHLSN CSNK2A1 DCAF8 DRC4 DVL2 FAM124A FAM133A FAM9A FGF10 FGF11 FGF12 FXR2 GOLGA7 GPATCH2L HNRNPLL HTATSF1 HYPK INO80B ITGA5 KANK2 KLF12 KRTAP10-7 L3MBTL2 LASP1 LMNB2 LMO3 LNX1 METTL13 MFAP1 MIS18A MORF4L1 MORF4L2 MRPL11 MRPL53 NDUFAB1 NKAP NKAPD1 NTAQ1 NUP62 PAWR PDIA6 PFKFB3 PHF1 PHF19 PID1 PNKP POLR2L POLR2M POMK POU6F2 PPIG PRKAA1 PRR20A PRR20B PRR20C PRR20D PRR20E QKI RAD54L2 RALY RALYL RBM10 RBM39 RIPPLY1 RNF170 RNF4 RP9P RPL22 RPS25 SAP30BP SERF2 SLU7 SPANXN2 SPMIP2 SREK1IP1 STRBP TCEA2 TCEANC TPM3 TPT1P8 TRAF5 TRIM26 TRIP10 TTLL10 TXN2 U2AF2 UBE2I VCX2 WT1 YES1 ZBTB48 ZCCHC10 ZGPAT ZMAT4 ZNF385C ZNF408 ZNF526
Entrez ID		84197	55145
HPRD ID		08668	15496
Ensembl ID		ENSG00000185900	ENSG00000131931
Uniprot IDs		Q9H5K3	Q9NVV9
PDB IDs			2JTG 2KO0 2L1G
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Positive Regulation Of Extracellular Matrix Organization Endothelial Cell Proliferation Regulation Of Chondrocyte Differentiation SMAD Binding Regulation Of Cartilage Development Protein Metabolic Process Regulation Of Extracellular Matrix Organization Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Population Proliferation HFE-transferrin Receptor Complex Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Receptor Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Chondrocyte Proliferation Glycoprotein Biosynthetic Process BMP Receptor Activity Macromolecule Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Macromolecule Biosynthetic Process Ovarian Cumulus Expansion Endochondral Bone Morphogenesis Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Myofibroblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Epithelial Cell Proliferation Regulation Of Protein Ubiquitination Ventricular Compact Myocardium Morphogenesis Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Parathyroid Gland Development Positive Regulation Of Tight Junction Disassembly Germ Cell Migration Vascular Endothelial Cell Proliferation Transforming Growth Factor Beta Receptor Activity Epicardium Morphogenesis Trophoblast Cell Migration Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Ligand-receptor Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Carbohydrate Homeostasis Non-canonical Inflammasome Complex Assembly Glucose Homeostasis Positive Regulation Of Transcription By Glucose	Nucleus RNA Splicing Nucleic Acid Binding RNA Binding Protein Binding MRNA Processing Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process PTB Domain Binding ESC/E(Z) Complex Regulation Of Nucleobase-containing Compound Metabolic Process RNA Processing MRNA Metabolic Process Positive Regulation Of Fat Cell Proliferation
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