SETD3 and APLNR

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		SETD3	APLNR
Description		SET domain containing 3, actin N3(tau)-histidine methyltransferase	apelin receptor
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Plasma Membrane Membrane
	Molecular Function	Transcription Coactivator Activity Actin Binding Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Protein-L-histidine N-tele-methyltransferase Activity Histone H3K4 Methyltransferase Activity Histone H3K36 Methyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Apelin Receptor Activity Mechanoreceptor Activity
	Biological Process	Chromatin Remodeling Peptidyl-histidine Methylation Peptidyl-lysine Trimethylation Actin Modification Methylation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Muscle Cell Differentiation Regulation Of Uterine Smooth Muscle Contraction	Angiogenesis Blood Vessel Development Vasculogenesis Vasculature Development Heart Looping G Protein-coupled Receptor Internalization Atrioventricular Valve Development Endocardial Cushion Formation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Heart Development Adult Heart Development Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Vascular Associated Smooth Muscle Cell Differentiation Aorta Development Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Apelin Receptor Signaling Pathway Ventricular Septum Morphogenesis Venous Blood Vessel Development Coronary Vasculature Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Gap Junction Assembly Positive Regulation Of G Protein-coupled Receptor Internalization
Pathways		PKMTs methylate histone lysines	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS		Scalp hair shape ( 26926045) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		4 interacting genes: APLNR APP MYOD1 SRPK1	8 interacting genes: AKR1B1 APLN GJB2 LAMP2 MARK4 MTCH1 NDRG4 SETD3
Entrez ID		84193	187
HPRD ID		08664	02503
Ensembl ID		ENSG00000183576	ENSG00000134817
Uniprot IDs		Q86TU7	B2RDH3 B3KQN4 P35414
PDB IDs		3SMT 6ICT 6ICV 6JAT 6MBJ 6MBK 6MBL 6OX0 6OX1 6OX2 6OX3 6OX4 6OX5 6V62 6V63 6WK1 6WK2 7LMS 7W28 7W29 8X77 8X8Q	2LOT 2LOU 2LOV 2LOW 5VBL 6KNM 7SUS 7W0L 7W0M 7W0N 7W0O 7W0P 8XQE 8XQF 8XQI 8XQJ 8XZF 8XZG 8XZH 8XZI 8XZJ 8Z74 8Z7J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Positive Regulation Of Receptor-mediated Endocytosis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Receptor Internalization Negative Regulation Of CAMP-mediated Signaling Muscle Cell Differentiation Mechanoreceptor Activity Apelin Receptor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Endocytosis Regulation Of Receptor-mediated Endocytosis Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Apelin Receptor Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Regulation Of RNA Splicing Myoblast Fate Determination Regulation Of MRNA Processing Skeletal Muscle Fiber Adaptation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Cellular Component Organization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Developmental Process Venous Blood Vessel Development Regulation Of Calcium Ion Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response	Prostaglandin H2 Endoperoxidase Reductase Activity L-glucuronate Reductase Activity Glyceraldehyde Oxidoreductase Activity Fructose Biosynthetic Process Glycerol Dehydrogenase (NADP+) Activity Chaperone-mediated Autophagy Translocation Complex Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Smooth Muscle Cell Proliferation Apelin Receptor Signaling Pathway Apelin Receptor Binding Peptidyl-histidine Methylation Protein-L-histidine N-tele-methyltransferase Activity
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