SETD3

Description		SET domain containing 3, actin N3(tau)-histidine methyltransferase
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coactivator Activity Actin Binding Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Protein-L-histidine N-tele-methyltransferase Activity Histone H3K4 Methyltransferase Activity Histone H3K36 Methyltransferase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Chromatin Remodeling Peptidyl-histidine Methylation Peptidyl-lysine Trimethylation Actin Modification Methylation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Muscle Cell Differentiation Regulation Of Uterine Smooth Muscle Contraction
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Scalp hair shape ( 26926045) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Novel Interacting Genes		4 novel interacting genes: APLNR APP MYOD1 SRPK1
Interacting Genes		4 interacting genes: APLNR APP MYOD1 SRPK1
Entrez ID		84193
HPRD ID		08664
Ensembl ID		ENSG00000183576
Uniprot IDs		Q86TU7
PDB IDs		3SMT 6ICT 6ICV 6JAT 6MBJ 6MBK 6MBL 6OX0 6OX1 6OX2 6OX3 6OX4 6OX5 6V62 6V63 6WK1 6WK2 7LMS 7W28 7W29 8X77 8X8Q
Enriched GO Terms of Interacting Partners?		Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Positive Regulation Of Receptor-mediated Endocytosis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Receptor Internalization Negative Regulation Of CAMP-mediated Signaling Muscle Cell Differentiation Mechanoreceptor Activity Apelin Receptor Activity Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Endocytosis Regulation Of Receptor-mediated Endocytosis Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transmembrane Transport Apelin Receptor Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Regulation Of RNA Splicing Myoblast Fate Determination Regulation Of MRNA Processing Skeletal Muscle Fiber Adaptation Negative Regulation Of Myoblast Proliferation Positive Regulation Of Cellular Component Organization Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Developmental Process Venous Blood Vessel Development Regulation Of Calcium Ion Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response
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