APLNR and LAMP2

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		APLNR	LAMP2
Description		apelin receptor	lysosomal associated membrane protein 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Autophagosome Membrane Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Endosome Membrane Membrane Phagocytic Vesicle Membrane Platelet Dense Granule Membrane Cytoplasmic Vesicle Late Endosome Membrane Azurophil Granule Membrane Lysosomal Lumen Autolysosome Perinuclear Region Of Cytoplasm Chaperone-mediated Autophagy Translocation Complex Extracellular Exosome Membrane Microdomain Ficolin-1-rich Granule Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Apelin Receptor Activity Mechanoreceptor Activity	Protein Binding Ion Channel Inhibitor Activity Enzyme Binding Protein Domain Specific Binding Signaling Adaptor Activity
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Vasculature Development Heart Looping G Protein-coupled Receptor Internalization Atrioventricular Valve Development Endocardial Cushion Formation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Heart Development Adult Heart Development Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Vascular Associated Smooth Muscle Cell Differentiation Aorta Development Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Apelin Receptor Signaling Pathway Ventricular Septum Morphogenesis Venous Blood Vessel Development Coronary Vasculature Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Gap Junction Assembly Positive Regulation Of G Protein-coupled Receptor Internalization	Protein Targeting Autophagy Lysosomal Lumen Acidification Cellular Response To Starvation Protein Import Protein Catabolic Process Negative Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Lysosomal Lumen PH Elevation Muscle Cell Cellular Homeostasis Protein Stabilization Chaperone-mediated Autophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Autophagosome Maturation Negative Regulation Of NLRP3 Inflammasome Complex Assembly Proton Transmembrane Transport Lysosomal Protein Catabolic Process
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Platelet degranulation Neutrophil degranulation Chaperone Mediated Autophagy
Drugs
Diseases			Danon disease; X-linked vacuolar cardiomyopathy and myopathy
GWAS
Interacting Genes		8 interacting genes: AKR1B1 APLN GJB2 LAMP2 MARK4 MTCH1 NDRG4 SETD3	6 interacting genes: AP4M1 APLNR CTSA PIAS4 SNCA UCHL1
Entrez ID		187	3920
HPRD ID		02503	02396
Ensembl ID		ENSG00000134817	ENSG00000005893
Uniprot IDs		B2RDH3 B3KQN4 P35414	P13473
PDB IDs		2LOT 2LOU 2LOV 2LOW 5VBL 6KNM 7SUS 7W0L 7W0M 7W0N 7W0O 7W0P 8XQE 8XQF 8XQI 8XQJ 8XZF 8XZG 8XZH 8XZI 8XZJ 8Z74 8Z7J	2MOF 2MOM
Enriched GO Terms of Interacting Partners?		Prostaglandin H2 Endoperoxidase Reductase Activity L-glucuronate Reductase Activity Glyceraldehyde Oxidoreductase Activity Fructose Biosynthetic Process Glycerol Dehydrogenase (NADP+) Activity Chaperone-mediated Autophagy Translocation Complex Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Smooth Muscle Cell Proliferation Apelin Receptor Signaling Pathway Apelin Receptor Binding Peptidyl-histidine Methylation Protein-L-histidine N-tele-methyltransferase Activity	Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Receptor Internalization Negative Regulation Of CAMP-mediated Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Mechanoreceptor Activity Apelin Receptor Activity Positive Regulation Of Calcium Ion Transmembrane Transport Regulation Of Autophagy Enzyme Activator Activity Response To Desipramine Adult Locomotory Behavior Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Signal Transduction Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Negative Regulation Of Cell Communication Positive Regulation Of Calcium Ion Transport Apelin Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Autophagy Negative Regulation Of Protein Catabolic Process Lumenal Side Of Lysosomal Membrane Positive Regulation Of Catabolic Process Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Limb Epidermis Development Regulation Of Sequestering Of Calcium Ion Positive Regulation Of G Protein-coupled Receptor Internalization Establishment Of Localization In Cell Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Regulation Of Generation Of Precursor Metabolites And Energy Axon Target Recognition Omega Peptidase Activity Male Germ Cell Proliferation Protein Localization To Basolateral Plasma Membrane Regulation Of Calcium Ion Transmembrane Transport Adult Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Endocytosis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Regulation Of Serotonin Uptake AP-4 Adaptor Complex
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