ULK1 and SMCR8

Number of citations of the paper that reports this interaction (PubMedID 30669939)
71

Data Source:
BioGRID (two hybrid)

		ULK1	SMCR8
Description		unc-51 like autophagy activating kinase 1	SMCR8-C9orf72 complex subunit
Image
GO Annotations	Cellular Component	Phagophore Assembly Site Autophagosome Membrane Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Axon Phagophore Assembly Site Membrane Recycling Endosome Omegasome Membrane Atg1/ULK1 Kinase Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Guanyl-nucleotide Exchange Factor Complex Cell Projection Synapse Presynapse Postsynapse Atg1/ULK1 Kinase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding Protein Serine Kinase Activity	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein Kinase Binding
	Biological Process	Autophagosome Assembly Mitophagy Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Signal Transduction Axonogenesis Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Autophagy Positive Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Macroautophagy Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels Cellular Response To Stress Piecemeal Microautophagy Of The Nucleus Response To Starvation Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Reticulophagy Protein-containing Complex Assembly Positive Regulation Of Autophagosome Assembly	Autophagy Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Negative Regulation Of Exocytosis Negative Regulation Of Immune Response Positive Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly Regulation Of TORC1 Signaling
Pathways		Macroautophagy Regulation of TNFR1 signaling TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy
Drugs		Fostamatinib
Diseases
GWAS		Body mass index ( 26426971) Mercury levels ( 26025379)	Change in neurofilament light levels ( 31295725) Diastolic blood pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		26 interacting genes: ATG13 BECN1 C1QBP CALCOCO2 EXOC8 GABARAP GABARAPL2 KLHL20 MAPK14 MBP MEFV MTOR MUL1 NEDD4L OCLN PEDS1 POLE PPP1CA PRKAA1 RIPK2 SDCBP SMCR8 STAMBP SYNGAP1 UBC USP20	6 interacting genes: ATG13 DRC3 FEM1B TBK1 TOM1L2 ULK1
Entrez ID		8408	140775
HPRD ID		11933	18075
Ensembl ID		ENSG00000177169	ENSG00000176994
Uniprot IDs		O75385	Q8TEV9
PDB IDs		4WNO 4WNP 5CI7 6HYO 6MNH 6QAS 8P5G 8P5H 8P5I 8P5J 8P5K 8P5L 8SOI 8SQZ 8SRM 8SV9 9C82 9F32	6LT0 6V4U 7EL6 7MGE 7O2W
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Autophagy Autophagosome Macroautophagy Autophagosome Assembly Autophagosome Organization Regulation Of Macroautophagy Positive Regulation Of Metabolic Process Vacuole Organization Intracellular Signaling Cassette Cytosol Positive Regulation Of Cellular Component Organization Apoptotic Process Positive Regulation Of Macroautophagy Cellular Response To Nitrogen Starvation Programmed Cell Death Cell Death Positive Regulation Of Organelle Organization Negative Regulation Of Intracellular Signal Transduction Catabolic Process Mitophagy Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-12 Production Autophagy Of Mitochondrion Regulation Of Immune Response P38MAPK Cascade Cellular Response To Starvation Cellular Response To Stress Negative Regulation Of Lysosome Organization Regulation Of Metabolic Process Regulation Of Chemokine Production Negative Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Catabolic Process Regulation Of Cellular Component Organization Response To Starvation Positive Regulation Of Protein-containing Complex Disassembly Post-translational Protein Modification Negative Regulation Of Macroautophagy Organelle Organization Regulation Of Signal Transduction Positive Regulation Of Growth Response To Mitochondrial Depolarisation Regulation Of Organelle Assembly Cellular Response To Nutrient Levels Regulation Of Protein Metabolic Process Regulation Of Innate Immune Response Xenophagy	Atg1/ULK1 Kinase Complex Phagophore Assembly Site Membrane Positive Regulation Of Autophagy Macroautophagy Microautophagy Nucleophagy Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Peptidyl-serine Phosphorylation Autophagy Mitophagy Regulation Of Autophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Positive Regulation Of Macroautophagy Autophagosome Organization Positive Regulation Of Catabolic Process Omegasome Membrane Epithelial Cell Maturation Involved In Prostate Gland Development Dendritic Cell Proliferation Intracellular Protein Localization Vacuole Organization Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Macroautophagy Catabolic Process Response To Mitochondrial Depolarisation Positive Regulation Of Xenophagy Positive Regulation Of TORC2 Signaling Cellular Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway T Follicular Helper Cell Differentiation Negative Regulation Of Collateral Sprouting Branching Involved In Prostate Gland Morphogenesis Regulation Of TORC2 Signaling
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