ULK1 and EXOC8

Number of citations of the paper that reports this interaction (PubMedID 21241894)
61

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		ULK1	EXOC8
Description		unc-51 like autophagy activating kinase 1	exocyst complex component 8
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Autophagosome Membrane Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Axon Phagophore Assembly Site Membrane Recycling Endosome Omegasome Membrane Atg1/ULK1 Kinase Complex	Exocyst Cytoplasm Late Endosome Cytosol Plasma Membrane Membrane Growth Cone Cell Projection Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding Protein Serine Kinase Activity	Protein Binding Small GTPase Binding Phosphatidylinositol Binding
	Biological Process	Autophagosome Assembly Mitophagy Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Signal Transduction Axonogenesis Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Autophagy Positive Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Macroautophagy Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels Cellular Response To Stress Piecemeal Microautophagy Of The Nucleus Response To Starvation Protein Autophosphorylation Negative Regulation Of Collateral Sprouting Axon Extension Reticulophagy Protein-containing Complex Assembly Positive Regulation Of Autophagosome Assembly	Mitotic Cytokinesis Exocytosis Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Endosome Organization Intracellular Protein Localization Protein Transport Regulation Of Macroautophagy Extracellular Matrix Disassembly Membrane Fission Vesicle Tethering Involved In Exocytosis
Pathways		Macroautophagy Regulation of TNFR1 signaling TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs		Fostamatinib
Diseases
GWAS		Body mass index ( 26426971) Mercury levels ( 26025379)	Hemoglobin concentration ( 27863252)
Interacting Genes		26 interacting genes: ATG13 BECN1 C1QBP CALCOCO2 EXOC8 GABARAP GABARAPL2 KLHL20 MAPK14 MBP MEFV MTOR MUL1 NEDD4L OCLN PEDS1 POLE PPP1CA PRKAA1 RIPK2 SDCBP SMCR8 STAMBP SYNGAP1 UBC USP20	88 interacting genes: AIMP2 ANKRD36B ATP23 BEX2 BICRAL BLOC1S2 BLOC1S6 BLZF1 BORCS6 CAPN3 CCDC33 CCDC85B CCHCR1 CDSN CEP57L1 CWF19L2 DMAP1 EFHC2 ELL2 ESS2 EXOC2 FAM217B GOLGA2 GRAMD4 GTF2E2 HGS IHO1 IKZF3 ISY1 ISY1-RAB43 KIAA1217 KIFC3 KRT15 KRT18 KRT19 KRT20 KRT31 KRT34 KRT36 KRT76 LNX1 LZTS1 MARCHF7 MBD3L1 MBIP MIPOL1 MTUS2 MYOZ3 NAB2 NDC80 NUP54 PBX4 PCM1 PRR35 RAB3IL1 RALA RAPGEF3 RINT1 RUSC1 SASH1 SCARA5 SNAPC1 STMN3 SYCE1 SYT17 TADA2A TBC1D22B TCF12 TCF4 TFIP11 TRIM14 TRIM21 TRIM27 TRIM54 ULK1 UQCC2 USHBP1 USP54 VPS16 VPS37B WASHC1 ZC2HC1A ZNF177 ZNF35 ZNF559-ZNF177 ZNF566 ZNF628 ZSCAN4
Entrez ID		8408	149371
HPRD ID		11933	09943
Ensembl ID		ENSG00000177169	ENSG00000116903
Uniprot IDs		O75385	Q8IYI6
PDB IDs		4WNO 4WNP 5CI7 6HYO 6MNH 6QAS 8P5G 8P5H 8P5I 8P5J 8P5K 8P5L 8SOI 8SQZ 8SRM 8SV9 9C82 9F32
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Autophagy Regulation Of Autophagy Positive Regulation Of Catabolic Process Autophagy Autophagosome Macroautophagy Autophagosome Assembly Autophagosome Organization Regulation Of Macroautophagy Positive Regulation Of Metabolic Process Vacuole Organization Intracellular Signaling Cassette Cytosol Positive Regulation Of Cellular Component Organization Apoptotic Process Positive Regulation Of Macroautophagy Cellular Response To Nitrogen Starvation Programmed Cell Death Cell Death Positive Regulation Of Organelle Organization Negative Regulation Of Intracellular Signal Transduction Catabolic Process Mitophagy Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-12 Production Autophagy Of Mitochondrion Regulation Of Immune Response P38MAPK Cascade Cellular Response To Starvation Cellular Response To Stress Negative Regulation Of Lysosome Organization Regulation Of Metabolic Process Regulation Of Chemokine Production Negative Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Catabolic Process Regulation Of Cellular Component Organization Response To Starvation Positive Regulation Of Protein-containing Complex Disassembly Post-translational Protein Modification Negative Regulation Of Macroautophagy Organelle Organization Regulation Of Signal Transduction Positive Regulation Of Growth Response To Mitochondrial Depolarisation Regulation Of Organelle Assembly Cellular Response To Nutrient Levels Regulation Of Protein Metabolic Process Regulation Of Innate Immune Response Xenophagy	Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Protein Binding Supramolecular Fiber Organization Intermediate Filament Organelle Organization Structural Molecule Activity Negative Regulation Of Viral Transcription Cytoskeleton Regulation Of Viral Transcription Regulation Of Post-translational Protein Modification Regulation Of Protein Autoubiquitination Molecular Adaptor Activity Cytoskeleton Organization Identical Protein Binding Phosphatidylinositol 3-kinase Inhibitor Activity Cellular Localization Vesicle-mediated Transport To The Plasma Membrane Regulation Of Lysosome Size BORC Complex Post-mRNA Release Spliceosomal Complex Gamma-tubulin Binding Autophagosome Epidermis Development
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