SMCR8

Description		SMCR8-C9orf72 complex subunit
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Guanyl-nucleotide Exchange Factor Complex Cell Projection Synapse Presynapse Postsynapse Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein Kinase Binding
	Biological Process	Autophagy Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Negative Regulation Of Exocytosis Negative Regulation Of Immune Response Positive Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly Regulation Of TORC1 Signaling
Pathways
Drugs
Diseases
GWAS		Change in neurofilament light levels ( 31295725) Diastolic blood pressure ( 30578418) Systolic blood pressure ( 30578418)
Novel Interacting Genes		6 novel interacting genes: ATG13 DRC3 FEM1B TBK1 TOM1L2 ULK1
Interacting Genes		6 interacting genes: ATG13 DRC3 FEM1B TBK1 TOM1L2 ULK1
Entrez ID		140775
HPRD ID		18075
Ensembl ID		ENSG00000176994
Uniprot IDs		Q8TEV9
PDB IDs		6LT0 6V4U 7EL6 7MGE 7O2W
Enriched GO Terms of Interacting Partners?		Atg1/ULK1 Kinase Complex Phagophore Assembly Site Membrane Positive Regulation Of Autophagy Macroautophagy Microautophagy Nucleophagy Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Peptidyl-serine Phosphorylation Autophagy Mitophagy Regulation Of Autophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Positive Regulation Of Macroautophagy Autophagosome Organization Positive Regulation Of Catabolic Process Omegasome Membrane Epithelial Cell Maturation Involved In Prostate Gland Development Dendritic Cell Proliferation Intracellular Protein Localization Vacuole Organization Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Macroautophagy Catabolic Process Response To Mitochondrial Depolarisation Positive Regulation Of Xenophagy Positive Regulation Of TORC2 Signaling Cellular Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway T Follicular Helper Cell Differentiation Negative Regulation Of Collateral Sprouting Branching Involved In Prostate Gland Morphogenesis Regulation Of TORC2 Signaling
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