DOHH and EIF5A

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		DOHH	EIF5A
Description		deoxyhypusine hydroxylase	eukaryotic translation initiation factor 5A
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GO Annotations	Cellular Component	Cytosol	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Synapse
	Molecular Function	Monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Deoxyhypusine Monooxygenase Activity Metal Ion Binding	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding
	Biological Process	Peptidyl-lysine Modification To Peptidyl-hypusine	Translation Translational Elongation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Hypusine synthesis from eIF5A-lysine	Hypusine synthesis from eIF5A-lysine
Drugs
Diseases
GWAS			Liver enzyme levels (alkaline phosphatase) ( 33972514) Venous thromboembolism ( 31420334)
Interacting Genes		2 interacting genes: EIF5A WEE2-AS1	19 interacting genes: CRX DHPS DOHH GSC2 LBX1 MEI4 MEOX2 PICK1 REL RPL5 SDCBP SENP1 STUB1 SUMO2 TGM2 UBE2I XPO1 XPO4 XRN2
Entrez ID		83475	1984
HPRD ID		14627	02555
Ensembl ID		ENSG00000129932	ENSG00000132507
Uniprot IDs		Q9BU89	P63241
PDB IDs		4D4Z 4D50	3CPF 5DLQ 8A0E 8Y0W
Enriched GO Terms of Interacting Partners?		Annulate Lamellae Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination Regulation Of Translational Termination Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Pre-mRNA 5'-splice Site Binding MRNA 5'-splice Site Recognition Regulation Of Translational Elongation U6 SnRNA Binding Translation Elongation Factor Activity U1 SnRNP Positive Regulation Of Protein-containing Complex Disassembly Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Signal Transduction By P53 Class Mediator MRNA Splice Site Recognition Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Translational Elongation Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Virus Ribosome Binding	Regulation Of Ubiquitin-dependent Protein Catabolic Process Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Sumoylation Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nuclear Export Signal Receptor Activity Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Nucleus Nuclear Export DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Deoxyhypusine Synthase Activity Focal Adhesion Interleukin-5 Receptor Complex Regulation Of Protein Catabolic Process Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Monoamine Transport Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity SUMO Conjugating Enzyme Activity Regulation Of Protein Export From Nucleus Protein Export From Nucleus Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Glutamatergic Neuron Differentiation Peptidyl-lysine Modification To Peptidyl-hypusine Deoxyhypusine Monooxygenase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Spermidine Catabolic Process Protein Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Interleukin-5 Receptor Binding Protein Deamination Cellular Response To Triglyceride Transcription Termination Site Sequence-specific DNA Binding Nuclear Transport Nucleocytoplasmic Transport
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