EIF5A and SENP1

Number of citations of the paper that reports this interaction (PubMedID 38229033)
90

Data Source:
BioGRID (enzymatic study)

		EIF5A	SENP1
Description		eukaryotic translation initiation factor 5A	SUMO specific peptidase 1
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GO Annotations	Cellular Component	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Synapse	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding	Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeSUMOylase Activity SUMO-specific Endopeptidase Activity
	Biological Process	Translation Translational Elongation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Proteolysis Regulation Of Definitive Erythrocyte Differentiation Protein Sumoylation Protein Desumoylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process MRNA Destabilization Regulation Of Primary Metabolic Process Regulation Of Postsynapse Assembly
Pathways		Hypusine synthesis from eIF5A-lysine	SUMO is proteolytically processed RHOF GTPase cycle
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Venous thromboembolism ( 31420334)	Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)
Interacting Genes		19 interacting genes: CRX DHPS DOHH GSC2 LBX1 MEI4 MEOX2 PICK1 REL RPL5 SDCBP SENP1 STUB1 SUMO2 TGM2 UBE2I XPO1 XPO4 XRN2	28 interacting genes: APP CAV3 EIF5A GCM1 HDAC1 HIPK1 HIPK2 KCNK1 KEAP1 MORC2 NACC1 PARP1 PIAS3 PIM1 PML PRIM1 RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28 USP7
Entrez ID		1984	29843
HPRD ID		02555	07153
Ensembl ID		ENSG00000132507	ENSG00000079387
Uniprot IDs		P63241	Q9P0U3
PDB IDs		3CPF 5DLQ 8A0E 8Y0W	2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Sumoylation Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nuclear Export Signal Receptor Activity Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Nucleus Nuclear Export DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Deoxyhypusine Synthase Activity Focal Adhesion Interleukin-5 Receptor Complex Regulation Of Protein Catabolic Process Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Monoamine Transport Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity SUMO Conjugating Enzyme Activity Regulation Of Protein Export From Nucleus Protein Export From Nucleus Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Glutamatergic Neuron Differentiation Peptidyl-lysine Modification To Peptidyl-hypusine Deoxyhypusine Monooxygenase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Spermidine Catabolic Process Protein Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Interleukin-5 Receptor Binding Protein Deamination Cellular Response To Triglyceride Transcription Termination Site Sequence-specific DNA Binding Nuclear Transport Nucleocytoplasmic Transport	Protein Sumoylation Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteolysis Protein Modification Process Post-translational Protein Modification Protein Metabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Regulation Of Proteasomal Protein Catabolic Process SUMO Transferase Activity Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process PML Body Organization Nucleus Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Protein Tag Activity Protein-containing Complex Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Intracellular Transport Cellular Response To Stress Cytoplasmic Periphery Of The Nuclear Pore Complex DNA Damage Response Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Nuclear Body Organization Negative Regulation Of Proteolysis Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Protein Localization Deubiquitinase Activity Maintenance Of Protein Location In Nucleus Ubiquitin-like Protein Ligase Binding Nuclear Pore Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Postsynaptic Cytosol Negative Regulation Of Transcription By RNA Polymerase II SUMO Ligase Complex Nuclear Pore Cytoplasmic Filaments
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