EIF5A and MEI4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EIF5A	MEI4
Description		eukaryotic translation initiation factor 5A	meiotic double-stranded break formation protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Synapse	Lateral Element Chromosome
	Molecular Function	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding	Protein Binding
	Biological Process	Translation Translational Elongation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Virus Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	DNA Recombination Homologous Chromosome Pairing At Meiosis Spermatogenesis Meiotic DNA Double-strand Break Formation Oogenesis Meiotic Cell Cycle
Pathways		Hypusine synthesis from eIF5A-lysine
Drugs
Diseases
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514) Venous thromboembolism ( 31420334)	Brain volume in infants (white matter) ( 28763065) Cadmium levels ( 26025379) Daytime nap ( 33568662) HDL cholesterol levels in HIV infection ( 33109212) Macular thickness ( 30535121)
Interacting Genes		19 interacting genes: CRX DHPS DOHH GSC2 LBX1 MEI4 MEOX2 PICK1 REL RPL5 SDCBP SENP1 STUB1 SUMO2 TGM2 UBE2I XPO1 XPO4 XRN2	36 interacting genes: AFMID AIRIM BAG4 C19orf25 CABP5 CDKN2D CHAF1A CPNE2 CST9L CTTNBP2 DNTT EIF5A FKBP6 GRB2 HSD3B7 IQGAP1 LGALS14 MACO1 METTL21A MLX MTMR9 MYO5B NGB NME7 OSGIN1 PAFAH1B3 PHYHIPL PLEKHA4 POLR1C R3HDM2 TRAPPC2L TRIM59 TSEN15 TSSK3 USHBP1 VPS26C
Entrez ID		1984	101928601
HPRD ID		02555
Ensembl ID		ENSG00000132507	ENSG00000269964
Uniprot IDs		P63241	A8MW99
PDB IDs		3CPF 5DLQ 8A0E 8Y0W
Enriched GO Terms of Interacting Partners?		Regulation Of Ubiquitin-dependent Protein Catabolic Process Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Sumoylation Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nuclear Export Signal Receptor Activity Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Nucleus Nuclear Export DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Deoxyhypusine Synthase Activity Focal Adhesion Interleukin-5 Receptor Complex Regulation Of Protein Catabolic Process Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Monoamine Transport Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity SUMO Conjugating Enzyme Activity Regulation Of Protein Export From Nucleus Protein Export From Nucleus Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Glutamatergic Neuron Differentiation Peptidyl-lysine Modification To Peptidyl-hypusine Deoxyhypusine Monooxygenase Activity Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Spermidine Catabolic Process Protein Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Interleukin-5 Receptor Binding Protein Deamination Cellular Response To Triglyceride Transcription Termination Site Sequence-specific DNA Binding Nuclear Transport Nucleocytoplasmic Transport
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