DRC3 and SMCR8

		DRC3	SMCR8
Description		dynein regulatory complex subunit 3	SMCR8-C9orf72 complex subunit
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GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection	Chromatin Nucleus Nucleoplasm Cytoplasm Guanyl-nucleotide Exchange Factor Complex Cell Projection Synapse Presynapse Postsynapse Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Binding	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein Kinase Binding
	Biological Process		Autophagy Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Negative Regulation Of Exocytosis Negative Regulation Of Immune Response Positive Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly Regulation Of TORC1 Signaling
Pathways
Drugs
Diseases
GWAS			Change in neurofilament light levels ( 31295725) Diastolic blood pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		12 interacting genes: EIF3E ELAC2 FUNDC2 GID4 MFHAS1 PLAGL1 SMCR8 SOD2 SPECC1 ZNF250 ZNF287 ZNF624	6 interacting genes: ATG13 DRC3 FEM1B TBK1 TOM1L2 ULK1
Entrez ID		83450	140775
HPRD ID		13181	18075
Ensembl ID		ENSG00000171962	ENSG00000176994
Uniprot IDs		B3KSC6 Q9H069	Q8TEV9
PDB IDs		8J07	6LT0 6V4U 7EL6 7MGE 7O2W
Enriched GO Terms of Interacting Partners?			Atg1/ULK1 Kinase Complex Phagophore Assembly Site Membrane Positive Regulation Of Autophagy Macroautophagy Microautophagy Nucleophagy Piecemeal Microautophagy Of The Nucleus Phagophore Assembly Site Peptidyl-serine Phosphorylation Autophagy Mitophagy Regulation Of Autophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Positive Regulation Of Macroautophagy Autophagosome Organization Positive Regulation Of Catabolic Process Omegasome Membrane Epithelial Cell Maturation Involved In Prostate Gland Development Dendritic Cell Proliferation Intracellular Protein Localization Vacuole Organization Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Macroautophagy Catabolic Process Response To Mitochondrial Depolarisation Positive Regulation Of Xenophagy Positive Regulation Of TORC2 Signaling Cellular Response To Nutrient Levels Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway T Follicular Helper Cell Differentiation Negative Regulation Of Collateral Sprouting Branching Involved In Prostate Gland Morphogenesis Regulation Of TORC2 Signaling
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