COMMD1 and CUL7

Number of citations of the paper that reports this interaction (PubMedID 21778237)
40

Data Source:
BioGRID (pull down)

		COMMD1	CUL7
Description		copper metabolism domain containing 1	cullin 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Cul2-RING Ubiquitin Ligase Complex Recycling Endosome	Anaphase-promoting Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Cullin-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex
	Molecular Function	Copper Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Sodium Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Nucleotide-excision Repair Golgi To Plasma Membrane Transport Protein Transport Positive Regulation Of Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Low-density Lipoprotein Particle Clearance Protein Localization To Cell Surface Cholesterol Homeostasis Plasma Membrane To Endosome Transport Copper Ion Homeostasis Regulation Of Plasma Lipoprotein Particle Levels Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Localization To Cell Surface	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Vasculogenesis Epithelial To Mesenchymal Transition Placenta Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Golgi Organization Regulation Of Mitotic Nuclear Division Insulin Receptor Signaling Pathway Protein Ubiquitination Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Dendrite Morphogenesis
Pathways		Neddylation	XBP1(S) activates chaperone genes Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			3M syndrome
GWAS		Age-related nuclear cataracts ( 33311586) Erectile dysfunction ( 30583798) Height ( 31562340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular volume ( 27863252) Nonalcoholic fatty liver disease ( 31311600)	Appendicular lean mass ( 33097823)
Interacting Genes		38 interacting genes: BAHCC1 BARD1 BRCA1 C2orf74 COMMD10 COMMD2 COMMD3 COMMD4 COMMD5 COMMD6 COMMD7 COMMD8 CUL1 CUL2 CUL3 CUL4A CUL4B CUL5 CUL7 ELOC GRSF1 HMGB2 KAT2A LIG4 NFKBIA PRKN RELA RIPPLY3 SLC12A2 SOCS1 SOD1 SPP1 TCEAL8 TMEM132D UPRT VHL WDPCP XIAP	10 interacting genes: COMMD1 FBXW8 MEGF10 MTDH MTNR1A PLXNB3 RBX1 SKP1 TP53 UBE2M
Entrez ID		150684	9820
HPRD ID		06253	09901
Ensembl ID		ENSG00000173163	ENSG00000044090
Uniprot IDs		Q8N668	A0A669KBH4 Q14999
PDB IDs		2H2M 8F2R 8F2U 8P0W	2JNG 7Z8B
Enriched GO Terms of Interacting Partners?		Cullin-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Ubiquitination Ubiquitin Protein Ligase Binding Protein Modification By Small Protein Conjugation Post-translational Protein Modification NF-kappaB Binding Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Cellular Response To Stress Protein Modification Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Intrinsic Apoptotic Signaling Pathway Nucleoplasm Positive Regulation Of Protein Linear Polyubiquitination Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Nucleus Regulation Of Multicellular Organismal Development Apoptotic Signaling Pathway Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cell Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway SCF Ubiquitin Ligase Complex Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Regulation Of DNA Damage Checkpoint Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Developmental Process Regulation Of Cellular Response To Insulin Stimulus Protein K6-linked Ubiquitination BRCA1-B Complex Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Intracellular Signal Transduction Catabolic Process Proteolysis Cellular Response To Radiation Cytoplasm Regulation Of Cytokine Production Negative Regulation Of Cell Communication	Cul7-RING Ubiquitin Ligase Complex Nucleotide-excision Repair NEDD8 Transferase Activity SCF Ubiquitin Ligase Complex Negative Regulation Of Mitophagy Regulation Of Proteolysis Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Proteolysis Protein Neddylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cullin Family Protein Binding Molecular Function Activator Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macroautophagy Copper Ion Binding Regulation Of Mitophagy DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Autophagy Of Mitochondrion Regulation Of Epithelial Cell Apoptotic Process Protein Monoubiquitination Protein Modification By Small Protein Conjugation Mitophagy SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cholesterol Import Interferon-mediated Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Autophagy Of Mitochondrion Regulation Of Neurogenesis Post-translational Protein Modification Apoptotic Process Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Cellular Response To UV Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Catabolic Process Regulation Of Autophagy NEDD8 Conjugating Enzyme Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Response To Insulin Stimulus Regulation Of Protein Catabolic Process Insulin Receptor Signaling Pathway
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