GKAP1 and HDDC3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		GKAP1	HDDC3
Description		G kinase anchoring protein 1	HD domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Signal Transduction CGMP-mediated Signaling Positive Regulation Of Insulin Receptor Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Chronotype ( 30696823) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Triglyceride levels ( 32154731)
Interacting Genes		23 interacting genes: AP3B1 C1orf35 DHFR FAM124B FXR2 HDDC3 HGS HSD11B1 KANK2 KAT5 L3MBTL2 MFAP1 NDN PHOSPHO2 PRKG1 RCOR3 SDCBP SH3BP4 SOX18 TLE1 UBQLN1 UBQLN4 ZCCHC10	15 interacting genes: AKAP9 APP CCDC172 CCHCR1 CEP57L1 CFTR EXOC5 GKAP1 GOLGA8EP GOLGA8F KIF7 MAGEA4 MSTO1 NMI TPM3
Entrez ID		80318	374659
HPRD ID		17042	14635
Ensembl ID		ENSG00000165113	ENSG00000184508
Uniprot IDs		Q5VSY0	Q8N4P3
PDB IDs			3NR1 5VXA
Enriched GO Terms of Interacting Partners?		Protein Localization To Vacuole Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Lysosome Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Targeting Positive Regulation Of Exosomal Secretion Aggrephagy Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Circadian Rhythm Regulation Of Exosomal Secretion Transcription Regulator Complex Epithelium Development Autophagy Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Metabolic Process Respiratory System Process Protein Targeting To Lysosome NADP Binding Response To Methotrexate Cortisol Dehydrogenase (NADP+) Activity 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Interleukin-5 Receptor Complex Vacuolar Transport Macroautophagy Histone H2AK5 Acetyltransferase Activity Regulation Of Autophagy Negative Regulation Of Double-strand Break Repair Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase Activity Negative Regulation Of DNA Repair	Cellular Response To CAMP Response To CAMP
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