GKAP1 and HSD11B1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GKAP1	HSD11B1
Description		G kinase anchoring protein 1	hydroxysteroid 11-beta dehydrogenase 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Identical Protein Binding	Steroid Binding Oxidoreductase Activity Protein Homodimerization Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity NADP Binding 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Cortisol Dehydrogenase (NADP+) Activity
	Biological Process	Signal Transduction CGMP-mediated Signaling Positive Regulation Of Insulin Receptor Signaling Pathway	Lipid Metabolic Process Steroid Catabolic Process Steroid Metabolic Process Lung Development
Pathways			Glucocorticoid biosynthesis Prednisone ADME
Drugs			NADH Carbenoxolone Nicotinamide adenine dinucleotide phosphate 2-(N-morpholino)ethanesulfonic acid Corticosterone INCB13739 (3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanone (5S)-2-{[(1S)-1-(4-Fluorophenyl)ethyl]amino}-5-(2-hydroxy-2-propanyl)-5-methyl-1,3-thiazol-4(5H)-one (2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazine 2-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamide (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide 1-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamide (5S)-2-(Cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-one 2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDE (1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE (5R)-2-[(2-Fluorophenyl)amino]-5-isopropyl-1,3-thiazol-4(5H)-one Glycyrrhizic acid
Diseases			Cortisone reductase deficiency (CRD)
GWAS		Age at first sexual intercourse ( 34211149) Chronotype ( 30696823) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Triglyceride levels ( 32154731)	Alopecia areata ( 25608926)
Interacting Genes		23 interacting genes: AP3B1 C1orf35 DHFR FAM124B FXR2 HDDC3 HGS HSD11B1 KANK2 KAT5 L3MBTL2 MFAP1 NDN PHOSPHO2 PRKG1 RCOR3 SDCBP SH3BP4 SOX18 TLE1 UBQLN1 UBQLN4 ZCCHC10	3 interacting genes: CD36 CENPF GKAP1
Entrez ID		80318	3290
HPRD ID		17042	07042
Ensembl ID		ENSG00000165113	ENSG00000117594
Uniprot IDs		Q5VSY0	P28845 X5D2L1
PDB IDs			1XU7 1XU9 2BEL 2ILT 2IRW 2RBE 3BYZ 3BZU 3CH6 3CZR 3D3E 3D4N 3D5Q 3EY4 3FCO 3FRJ 3H6K 3HFG 3OQ1 3PDJ 3QQP 3TFQ 4BB5 4BB6 4C7J 4C7K 4HFR 4HX5 4IJU 4IJV 4IJW 4K1L 4P38 4YYZ 5PGU 5PGV 5PGW 5PGX 5PGY 5QII
Enriched GO Terms of Interacting Partners?		Protein Localization To Vacuole Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Localization To Lysosome Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Targeting Positive Regulation Of Exosomal Secretion Aggrephagy Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Circadian Rhythm Regulation Of Exosomal Secretion Transcription Regulator Complex Epithelium Development Autophagy Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Metabolic Process Respiratory System Process Protein Targeting To Lysosome NADP Binding Response To Methotrexate Cortisol Dehydrogenase (NADP+) Activity 11-beta-hydroxysteroid Dehydrogenase (NADP+) Activity 7-beta-hydroxysteroid Dehydrogenase (NADP+) Activity Interleukin-5 Receptor Complex Vacuolar Transport Macroautophagy Histone H2AK5 Acetyltransferase Activity Regulation Of Autophagy Negative Regulation Of Double-strand Break Repair Negative Regulation Of Store-operated Calcium Channel Activity Polyubiquitin Modification-dependent Protein Binding Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase Activity Negative Regulation Of DNA Repair	CGMP-mediated Signaling Oleate Transmembrane Transporter Activity Short-chain Fatty Acid Transport Response To Linoleic Acid Lipoteichoic Acid Immune Receptor Activity Long-chain Fatty Acid Import Across Plasma Membrane Thrombospondin Receptor Activity Short-chain Fatty Acid Transmembrane Transporter Activity Positive Regulation Of Blood Microparticle Formation Oxidised Low-density Lipoprotein Particle Receptor Activity Triglyceride Transport Low-density Lipoprotein Particle Mediated Signaling Oxidised Low-density Lipoprotein Particle Clearance Intestinal Cholesterol Absorption Response To Bacterial Lipoprotein Positive Regulation Of Cholesterol Storage Lipoprotein Particle Binding Intracellular Signal Transduction Cellular Response To Lipoteichoic Acid Regulation Of Removal Of Superoxide Radicals Regulation Of Response To Reactive Oxygen Species Response To Stilbenoid Nitric Oxide-cGMP-mediated Signaling Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Cholesterol Import Intestinal Lipid Absorption Amyloid-beta Clearance By Cellular Catabolic Process Toll-like Receptor Binding Cellular Response To Hydroperoxide Long-chain Fatty Acid Import Into Cell Cellular Response To Bacterial Lipopeptide Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Phagocytosis, Engulfment Lipid Transport Across Blood-brain Barrier Cellular Response To Diacyl Bacterial Lipopeptide Lipid Import Into Cell High-density Lipoprotein Particle Binding Phagocytosis, Recognition Kinetochore Assembly Ciliary Transition Fiber Pronucleus Low-density Lipoprotein Particle Receptor Activity Low-density Lipoprotein Particle Clearance Lipoprotein Transport Low-density Lipoprotein Particle Binding Platelet Alpha Granule Membrane Long-chain Fatty Acid Transmembrane Transporter Activity Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Kinetochore Organization Positive Regulation Of Macrophage Derived Foam Cell Differentiation
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