THOC7 and MED22

Number of citations of the paper that reports this interaction (PubMedID 12584197)
0

Data Source:
BioGRID (pull down)

		THOC7	MED22
Description		THO complex subunit 7	mediator complex subunit 22
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GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Mediator Complex Core Mediator Complex
	Molecular Function	RNA Binding Protein Binding	Transcription Coregulator Activity Protein Binding
	Biological Process	MRNA Processing MRNA Export From Nucleus RNA Splicing MRNA Transport	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Neutrophil count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 28991256 29483656 30285260) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)	Blood protein levels in cardiovascular risk ( 28369058) Malaria ( 31844061)
Interacting Genes		11 interacting genes: CCDC146 CHD3 CKAP4 GOT2 MED22 MED8 MNS1 NDC80 NIF3L1 SMARCD1 THOC5	13 interacting genes: CEBPA FBXO7 GOLM1 HGS MED11 MED17 MED27 MED30 MED8 MED9 NTAQ1 THOC7 TXNDC9
Entrez ID		80145	6837
HPRD ID		17632	01713
Ensembl ID		ENSG00000163634	ENSG00000148297
Uniprot IDs		A0A5S6STF9 Q6I9Y2	Q15528
PDB IDs		7APK 7ZNK 7ZNL	7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Transcription Coregulator Activity Core Mediator Complex Sperm Axoneme Assembly Mediator Complex Microtubule-based Process L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of DNA-templated Transcription Initiation Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly G2/MI Transition Of Meiotic Cell Cycle Kinetochore Adaptor Activity Axoneme Assembly Microtubule Bundle Formation Positive Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Positive Regulation Of DNA-templated Transcription L-aspartate Catabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Primitive Hemopoiesis Nuclear Speck Meiotic Cell Cycle Phase Transition Ndc80 Complex Spindle Assembly Involved In Female Meiosis I Sperm Motility Flagellated Sperm Motility Axoneme Cilium-dependent Cell Motility Sperm Flagellum Regulation Of Chromosome Segregation THO Complex Skeletal Muscle Satellite Cell Proliferation Cilium Movement Involved In Cell Motility Positive Regulation Of RNA Metabolic Process THO Complex Part Of Transcription Export Complex Aspartate Metabolic Process Lamellar Body Polymeric Cytoskeletal Fiber	Core Mediator Complex Positive Regulation Of DNA-templated Transcription Initiation Regulation Of DNA-templated Transcription Initiation Mediator Complex RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Ubiquitin Ligase Complex Protein-DNA Complex Assembly Transcription Coregulator Activity Protein Ubiquitination Ubiquitin Protein Ligase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Transcription By RNA Polymerase II Somatic Stem Cell Population Maintenance Post-translational Protein Modification Nuclear Vitamin D Receptor Binding Protein Modification Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Stem Cell Population Maintenance Maintenance Of Cell Number Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Nuclear Thyroid Hormone Receptor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Organization Nucleoplasm Transcription Initiation At RNA Polymerase II Promoter Nucleus Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Protein-N-terminal Glutamine Amidohydrolase Activity Cellular Component Assembly Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Response To Vitamin B2
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