THOC7

Description		THO complex subunit 7
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GO Annotations	Cellular Component	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	RNA Binding Protein Binding
	Biological Process	MRNA Processing MRNA Export From Nucleus RNA Splicing MRNA Transport
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Neutrophil count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 28991256 29483656 30285260) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)
Novel Interacting Genes		11 novel interacting genes: CCDC146 CHD3 CKAP4 GOT2 MED22 MED8 MNS1 NDC80 NIF3L1 SMARCD1 THOC5
Interacting Genes		11 interacting genes: CCDC146 CHD3 CKAP4 GOT2 MED22 MED8 MNS1 NDC80 NIF3L1 SMARCD1 THOC5
Entrez ID		80145
HPRD ID		17632
Ensembl ID		ENSG00000163634
Uniprot IDs		A0A5S6STF9 Q6I9Y2
PDB IDs		7APK 7ZNK 7ZNL
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Organization Transcription Coregulator Activity Core Mediator Complex Sperm Axoneme Assembly Mediator Complex Microtubule-based Process L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of DNA-templated Transcription Initiation Positive Regulation Of DNA-templated Transcription Initiation Positive Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Transcription Preinitiation Complex Assembly G2/MI Transition Of Meiotic Cell Cycle Kinetochore Adaptor Activity Axoneme Assembly Microtubule Bundle Formation Positive Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Positive Regulation Of DNA-templated Transcription L-aspartate Catabolic Process Trans-4-hydroxy-L-proline Catabolic Process Kynurenine-oxoglutarate Transaminase Activity Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Primitive Hemopoiesis Nuclear Speck Meiotic Cell Cycle Phase Transition Ndc80 Complex Spindle Assembly Involved In Female Meiosis I Sperm Motility Flagellated Sperm Motility Axoneme Cilium-dependent Cell Motility Sperm Flagellum Regulation Of Chromosome Segregation THO Complex Skeletal Muscle Satellite Cell Proliferation Cilium Movement Involved In Cell Motility Positive Regulation Of RNA Metabolic Process THO Complex Part Of Transcription Export Complex Aspartate Metabolic Process Lamellar Body Polymeric Cytoskeletal Fiber
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