DENND2D and HNRNPLL

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		DENND2D	HNRNPLL
Description		DENN domain containing 2D	heterogeneous nuclear ribonucleoprotein L like
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleus Membrane Synapse Ribonucleoprotein Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process		MRNA Processing Positive Regulation Of RNA Splicing Regulation Of RNA Splicing
Pathways		RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Lung function (FEV1/FVC) ( 26635082 30804560) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Peak expiratory flow ( 30804560) Platelet count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Body mass index ( 28892062)
Interacting Genes		2 interacting genes: FAM9B HNRNPLL	67 interacting genes: ADAMTSL4 ATXN1 BANP BARD1 BCAS2 BHLHE40 BOLL CALCOCO2 CEBPA DAB1 DDX39A DDX39B DENND2D DHX57 EFHC2 EIF4ENIF1 FAM9B GOPC GTF2A1 HNRNPK HOOK1 IKZF3 KHDRBS2 KRT31 KRT40 KRTAP10-3 MAGED1 MAP4K3 MDFI MID2 MREG NRG2 OTOF PAXIP1 PCBP1 PCBP3 PNMA1 POLR1F PRPF6 PRSS8 PTBP1 QKI RBM10 RBM3 RBPMS REL RHOXF2 SKIL SNRPA SPRY2 SRSF11 SRSF7 SSX2IP SUMO2 TADA2A THAP1 TLE5 TMCC2 TMEM178A TRIM23 TRIM27 TRIM29 UBE2I USP10 VAC14 WEE2-AS1 ZNF311
Entrez ID		79961	92906
HPRD ID		08655	13667
Ensembl ID		ENSG00000162777	ENSG00000143889
Uniprot IDs		Q9H6A0	A0A0S2Z6K1 A8K894 Q8WVV9
PDB IDs			7EVS
Enriched GO Terms of Interacting Partners?			Nucleic Acid Binding Identical Protein Binding RNA Binding Regulation Of MRNA Processing MRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Processing RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process PML Body MRNA Metabolic Process Nucleus Regulation Of RNA Splicing Regulation Of Transcription By RNA Polymerase II Nuclear Speck RNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Nucleic Acid Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Response To Cytokine Response To Peptide Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process SUMO Transferase Activity Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process MRNA Stabilization Nuclear Export Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process
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