HNRNPLL and NRG2

		HNRNPLL	NRG2
Description		heterogeneous nuclear ribonucleoprotein L like	neuregulin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Membrane Synapse Ribonucleoprotein Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding	Signaling Receptor Binding Growth Factor Activity
	Biological Process	MRNA Processing Positive Regulation Of RNA Splicing Regulation Of RNA Splicing	Signal Transduction Nervous System Development Intracellular Signal Transduction ERBB4 Signaling Pathway Animal Organ Development
Pathways			Signaling by ERBB2 Signaling by ERBB4 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Body mass index ( 28892062)	Body mass index ( 26426971) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		67 interacting genes: ADAMTSL4 ATXN1 BANP BARD1 BCAS2 BHLHE40 BOLL CALCOCO2 CEBPA DAB1 DDX39A DDX39B DENND2D DHX57 EFHC2 EIF4ENIF1 FAM9B GOPC GTF2A1 HNRNPK HOOK1 IKZF3 KHDRBS2 KRT31 KRT40 KRTAP10-3 MAGED1 MAP4K3 MDFI MID2 MREG NRG2 OTOF PAXIP1 PCBP1 PCBP3 PNMA1 POLR1F PRPF6 PRSS8 PTBP1 QKI RBM10 RBM3 RBPMS REL RHOXF2 SKIL SNRPA SPRY2 SRSF11 SRSF7 SSX2IP SUMO2 TADA2A THAP1 TLE5 TMCC2 TMEM178A TRIM23 TRIM27 TRIM29 UBE2I USP10 VAC14 WEE2-AS1 ZNF311	5 interacting genes: DAXX ERBB3 ERBB4 FBN2 HNRNPLL
Entrez ID		92906	9542
HPRD ID		13667	04821
Ensembl ID		ENSG00000143889	ENSG00000158458
Uniprot IDs		A0A0S2Z6K1 A8K894 Q8WVV9	F5GZS7 O14511
PDB IDs		7EVS
Enriched GO Terms of Interacting Partners?		Nucleic Acid Binding Identical Protein Binding RNA Binding Regulation Of MRNA Processing MRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Processing RNA Splicing Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process PML Body MRNA Metabolic Process Nucleus Regulation Of RNA Splicing Regulation Of Transcription By RNA Polymerase II Nuclear Speck RNA Processing Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Nucleic Acid Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Response To Cytokine Response To Peptide Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process SUMO Transferase Activity Regulation Of Metabolic Process Spliceosomal Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process MRNA Stabilization Nuclear Export Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process	Neuregulin Receptor Activity ERBB2 Signaling Pathway Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Extrinsic Apoptotic Signaling Pathway Cellular Response To Diamide Positive Regulation Of Cardiac Muscle Tissue Development ERBB3:ERBB2 Complex Protein Tyrosine Kinase Activity Central Nervous System Morphogenesis Establishment Of Planar Polarity Involved In Nephron Morphogenesis Cell Death Apoptotic Process Cellular Response To Sodium Arsenite Programmed Cell Death ErbB-3 Class Receptor Binding Positive Regulation Of Epithelial Cell Proliferation Receptor Complex Neuregulin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cardiac Muscle Tissue Development Cardiac Muscle Tissue Regeneration Olfactory Bulb Interneuron Differentiation ERBB2-ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Activity Sequestering Of TGFbeta In Extracellular Matrix Response To Sodium Arsenite Cellular Response To Salt ERBB4-ERBB4 Signaling Pathway Basolateral Plasma Membrane Schwann Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Heart Development ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Bone Trabecula Formation Ubiquitin Protein Ligase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Motor Neuron Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Neuron Migration Extracellular Negative Regulation Of Signal Transduction Extracellular Matrix Constituent Conferring Elasticity Apoptotic Signaling Pathway Endocardial Cushion Development
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