SRD5A3 and ADK

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SRD5A3	ADK
Description		steroid 5 alpha-reductase 3	adenosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity Polyprenol Reductase Activity Polyprenal Reductase Activity	Nucleotide Binding RNA Binding Adenosine Kinase Activity Deoxyadenosine Kinase Activity ATP Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Androgen Biosynthetic Process Polyprenol Catabolic Process Dolichyl Monophosphate Biosynthetic Process	Purine Nucleobase Metabolic Process Purine Ribonucleoside Salvage DATP Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process GMP Salvage AMP Salvage DAMP Salvage
Pathways		Androgen biosynthesis Synthesis of dolichyl-phosphate Defective SRD5A3 causes SRD5A3-CDG, KHRZ	Purine salvage Ribavirin ADME
Drugs		Spironolactone	Adenosine phosphate 7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE 5-[4-(DIMETHYLAMINO)PHENYL]-6-[(6-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYNYL]PYRIMIDIN-4-AMINE
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) PR interval ( 32439900) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adult body size ( 32376654) Cardiac troponin-I levels ( 31014085) Diverticular disease ( 30177863) Drug experimentation measurement ( 30718321) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hypospadias ( 25108383) Lymphocyte count ( 32888494) Permanent tooth development ( 21931568) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systolic blood pressure ( 30578418)
Interacting Genes		2 interacting genes: ADK NUDT15	3 interacting genes: FICD PLEKHA5 SRD5A3
Entrez ID		79644	132
HPRD ID		07825	00039
Ensembl ID		ENSG00000128039	ENSG00000156110
Uniprot IDs		A0A7P0TBH6 Q9H8P0	A0A140VJE0 A0A5F9ZH31 A0A5F9ZH72 A0A5F9ZHJ1 P55263
PDB IDs			1BX4 2I6A 2I6B 4O1L
Enriched GO Terms of Interacting Partners?		Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Metabolic Process DATP Biosynthetic Process Adenosine Kinase Activity Deoxyadenosine Kinase Activity DAMP Salvage 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity 8-oxo-dGDP Phosphatase Activity DGTP Metabolic Process DGTP Catabolic Process 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity Purine Nucleotide Metabolic Process DATP Metabolic Process Purine Deoxyribonucleoside Triphosphate Catabolic Process GMP Salvage Nucleotide Metabolic Process Deoxyribonucleoside Triphosphate Catabolic Process Purine Ribonucleoside Salvage Purine-containing Compound Metabolic Process AMP Salvage Nucleoside Triphosphate Diphosphatase Activity DNA Protection Nucleoside Phosphate Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Nucleoside Triphosphate Catabolic Process Nucleoside Salvage AMP Biosynthetic Process GMP Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Carbohydrate Derivative Metabolic Process Purine Nucleobase Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process AMP Metabolic Process Organophosphate Metabolic Process Purine Nucleoside Metabolic Process Purine Nucleotide Salvage Xenobiotic Catabolic Process GMP Metabolic Process Deoxyribose Phosphate Catabolic Process Deoxyribonucleotide Catabolic Process Purine-containing Compound Salvage Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Nucleoside Metabolic Process Phosphate-containing Compound Metabolic Process Small Molecule Metabolic Process Nucleoside Monophosphate Metabolic Process Purine Nucleotide Catabolic Process	Protein Adenylylhydrolase Activity AMPylase Activity Protein Adenylylation Protein Deadenylylation Polyprenol Reductase Activity Polyprenal Reductase Activity 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity 3-oxo-5-alpha-steroid 4-dehydrogenase Activity Polyprenol Catabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Androgen Biosynthetic Process Negative Regulation Of GTPase Activity Regulation Of IRE1-mediated Unfolded Protein Response Dolichol-linked Oligosaccharide Biosynthetic Process Phosphatidylinositol-5-phosphate Binding Reproductive System Development Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Androgen Metabolic Process Steroid Hormone Biosynthetic Process Alcohol Catabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Endoplasmic Reticulum Unfolded Protein Response Hormone Biosynthetic Process Phosphatidylinositol-3-phosphate Binding Hsp70 Protein Binding Endoplasmic Reticulum Membrane Response To Unfolded Protein Steroid Biosynthetic Process Regulation Of Response To Endoplasmic Reticulum Stress Protein-folding Chaperone Binding Nucleotidyltransferase Activity Isoprenoid Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?