SRD5A3

Description		steroid 5 alpha-reductase 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	3-oxo-5-alpha-steroid 4-dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity Polyprenol Reductase Activity Polyprenal Reductase Activity
	Biological Process	Protein Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Androgen Biosynthetic Process Polyprenol Catabolic Process Dolichyl Monophosphate Biosynthetic Process
Pathways		Androgen biosynthesis Synthesis of dolichyl-phosphate Defective SRD5A3 causes SRD5A3-CDG, KHRZ
Drugs		Spironolactone
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) PR interval ( 32439900) Subcortical volume (MOSTest) ( 32665545) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Novel Interacting Genes		2 novel interacting genes: ADK NUDT15
Interacting Genes		2 interacting genes: ADK NUDT15
Entrez ID		79644
HPRD ID		07825
Ensembl ID		ENSG00000128039
Uniprot IDs		A0A7P0TBH6 Q9H8P0
PDB IDs
Enriched GO Terms of Interacting Partners?		Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Metabolic Process DATP Biosynthetic Process Adenosine Kinase Activity Deoxyadenosine Kinase Activity DAMP Salvage 8-oxo-7,8-dihydroguanosine Triphosphate Pyrophosphatase Activity 8-oxo-dGDP Phosphatase Activity DGTP Metabolic Process DGTP Catabolic Process 8-oxo-7,8-dihydrodeoxyguanosine Triphosphate Pyrophosphatase Activity Purine Nucleotide Metabolic Process DATP Metabolic Process Purine Deoxyribonucleoside Triphosphate Catabolic Process GMP Salvage Nucleotide Metabolic Process Deoxyribonucleoside Triphosphate Catabolic Process Purine Ribonucleoside Salvage Purine-containing Compound Metabolic Process AMP Salvage Nucleoside Triphosphate Diphosphatase Activity DNA Protection Nucleoside Phosphate Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleobase-containing Small Molecule Metabolic Process Nucleoside Triphosphate Catabolic Process Nucleoside Salvage AMP Biosynthetic Process GMP Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Carbohydrate Derivative Metabolic Process Purine Nucleobase Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process AMP Metabolic Process Organophosphate Metabolic Process Purine Nucleoside Metabolic Process Purine Nucleotide Salvage Xenobiotic Catabolic Process GMP Metabolic Process Deoxyribose Phosphate Catabolic Process Deoxyribonucleotide Catabolic Process Purine-containing Compound Salvage Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Nucleoside Metabolic Process Phosphate-containing Compound Metabolic Process Small Molecule Metabolic Process Nucleoside Monophosphate Metabolic Process Purine Nucleotide Catabolic Process
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