MBOAT7 and MAPK6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MBOAT7	MAPK6
Description		membrane bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7	mitogen-activated protein kinase 6
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity 2-acylglycerol-3-phosphate O-acyltransferase Activity Lysophospholipid Acyltransferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phospholipid Biosynthetic Process Ventricular System Development Layer Formation In Cerebral Cortex Lipid Modification Phosphatidylinositol Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylinositol Metabolic Process Regulation Of Triglyceride Metabolic Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development
Pathways		Acyl chain remodelling of PI	MAPK6/MAPK4 signaling
Drugs			Acetylsalicylic acid Minocycline Colforsin
Diseases
GWAS		Cirrhosis (alcohol related) ( 26482880 32853455) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alkaline phosphatase) ( 33972514) Obesity-related traits ( 23251661) Phosphatidylinositol levels ( 31551469) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748)	Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		8 interacting genes: ADRA1A BDKRB1 FNDC3B MAPK6 SHANK3 STING1 UBC UNC93B1	168 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TCF12 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775
Entrez ID		79143	5597
HPRD ID		06925	04213
Ensembl ID		ENSG00000125505	ENSG00000069956
Uniprot IDs		Q96N66	Q16659
PDB IDs		8ERC	6YKY 6YLC 6YLL 7AQB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Intracellular Signal Transduction Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure MAPK Cascade Bradykinin Receptor Activity Regulation Of Dendritic Spine Development Septin Cytoskeleton Positive Regulation Of Dendritic Spine Development Cytoplasmic Pattern Recognition Receptor Signaling Pathway Guanylate Kinase-associated Protein Clustering Cyclic-di-GMP Binding STING Complex 2',3'-cyclic GMP-AMP Binding Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Neuron-glial Cell Signaling Positive Regulation Of Synaptic Transmission T Cell Antigen Processing And Presentation Toll-like Receptor 7 Signaling Pathway Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering Positive Regulation Of Cardiac Muscle Contraction Signal Transduction Regulation Of Blood Pressure Regulation Of The Force Of Heart Contraction By Chemical Signal Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Action Potential Adrenergic Receptor Activity Mitochondrial Outer Membrane Innate Immune Response-activating Signaling Pathway Toll-like Receptor Binding Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Vocal Learning Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Observational Learning Proton Channel Activity Positive Regulation Of CGAS/STING Signaling Pathway	Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding
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