MAPK6 and HAUS2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MAPK6	HAUS2
Description		mitogen-activated protein kinase 6	HAUS augmin like complex subunit 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Septin Cytoskeleton Protein-containing Complex	Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule HAUS Complex Mitotic Spindle Microtubule
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Heterodimerization Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Signal Transduction Intracellular Signal Transduction Positive Regulation Of Dendritic Spine Development	Microtubule Nucleation Centrosome Cycle Regulation Of Microtubule Nucleation Microtubule Organizing Center Organization Spindle Assembly Cell Division
Pathways		MAPK6/MAPK4 signaling	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Acetylsalicylic acid Minocycline Colforsin
Diseases
GWAS		Frailty index ( 34431594) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Bipolar disorder ( 31043756) Glucose homeostasis traits ( 25524916)
Interacting Genes		168 interacting genes: ACTG1 ACTR1B AMPH ANAPC5 ANK3 ANKRD2 APBA2 ARHGDIA ARPC3 ATG9A ATP5PF BAG6 BARX1 BBS10 BTRC CA1 CA12 CALR CASP6 CCND3 CCT3 CDH13 CERS1 CFAP298 CFL1 CNTN1 CNTRL COPS6 CSE1L CYRIB CYTH2 DBN1 DCTN2 DDOST DDR1 DGKZ DKC1 DNAJC28 DPPA4 DST DYNC2I2 EDF1 EEF1A2 EIF1 EIF3C EIF4A1 ELOF1 EMD FBXL16 FOXO3 FXYD3 GALNT7 GATA1 GLRX3 GORASP1 GPX1 HACL1 HAUS2 HDAC11 HIP1 HNRNPA0 HNRNPD HNRNPH3 HSP90AB1 HSP90B1 HSPD1 IDH3B INS ITGB3BP ITSN1 JUNB KDSR KLC1 KNSTRN LPXN MAP3K12 MAP3K7 MAPKAPK5 MASP1 MBIP MBOAT7 MCM3 MDK METTL17 METTL2A MGAT1 MIPEP MOK MON1A MTG2 MYBL2 MYOZ3 MZB1 NAT9 NAXE NDUFS6 NECTIN2 NELFB NOL4 NRXN2 NUDT5 OSTF1 PDCD6IP PDLIM1 PHACTR3 PHC2 PHGDH PIH1D1 PLEKHM1 PLSCR1 PPBP PPP1R7 PPP2R1A PRKAB1 PRKAR1A PRKCB PRPF38A PSAT1 PSIP1 PTPMT1 RAB2A RAB31 RACK1 RANBP9 RAP1GAP RARA RBL1 RGS19 RPL10 RRP7A SEPTIN3 SEPTIN5 SERPINA4 SHC1 SLC20A1 SLC41A3 SMAD6 SMS SNAPC4 SNW1 SOCS3 SPG7 SPRR2D SPTAN1 SRSF5 STX7 TCF12 TDP2 THAP4 TPI1 TTK TUBA1A UBA52 UBE2L3 URB1 USP20 VPS26C WDR26 WFS1 WWC1 XPO1 ZNF133 ZNF205 ZNF331 ZNF579 ZNF600 ZNF671 ZNF775	3 interacting genes: FXYD6 MAPK6 XRCC4
Entrez ID		5597	55142
HPRD ID		04213	07675
Ensembl ID		ENSG00000069956	ENSG00000137814
Uniprot IDs		Q16659	H3BP16 Q9NVX0
PDB IDs		6YKY 6YLC 6YLL 7AQB	7SQK
Enriched GO Terms of Interacting Partners?		Cytosol Cytoplasm Nucleus Protein Binding Extracellular Exosome Ubiquitin Protein Ligase Binding	Septin Cytoskeleton FHA Domain Binding Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Phospholipid Translocation DNA-dependent Protein Kinase-DNA Ligase 4 Complex Positive Regulation Of Ligase Activity Immunoglobulin V(D)J Recombination DNA Ligase IV Complex Nonhomologous End Joining Complex Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity MAP Kinase Activity Response To Lithium Ion Regulation Of Plasma Membrane Organization Cellular Response To Lithium Ion Positive Regulation Of Phospholipid Transport Positive Regulation Of Sodium Ion Transmembrane Transport V(D)J Recombination Response To X-ray Protein Localization To Site Of Double-strand Break Positive Regulation Of Dendritic Spine Development Somatic Recombination Of Immunoglobulin Gene Segments Condensed Chromosome Base-excision Repair Positive Regulation Of Transport Regulation Of Sodium Ion Transmembrane Transport Sodium Channel Regulator Activity Positive Regulation Of Sodium Ion Transport Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Regulation Of Membrane Lipid Distribution Regulation Of Dendritic Spine Development Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Sodium Ion Transport
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