MBOAT7

Description		membrane bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity 2-acylglycerol-3-phosphate O-acyltransferase Activity Lysophospholipid Acyltransferase Activity
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phospholipid Biosynthetic Process Ventricular System Development Layer Formation In Cerebral Cortex Lipid Modification Phosphatidylinositol Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylinositol Metabolic Process Regulation Of Triglyceride Metabolic Process
Pathways		Acyl chain remodelling of PI
Drugs
Diseases
GWAS		Cirrhosis (alcohol related) ( 26482880 32853455) Lipoprotein (a) levels ( 33730874) Liver enzyme levels (alkaline phosphatase) ( 33972514) Obesity-related traits ( 23251661) Phosphatidylinositol levels ( 31551469) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748)
Novel Interacting Genes		8 novel interacting genes: ADRA1A BDKRB1 FNDC3B MAPK6 SHANK3 STING1 UBC UNC93B1
Interacting Genes		8 interacting genes: ADRA1A BDKRB1 FNDC3B MAPK6 SHANK3 STING1 UBC UNC93B1
Entrez ID		79143
HPRD ID		06925
Ensembl ID		ENSG00000125505
Uniprot IDs		Q96N66
PDB IDs		8ERC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Intracellular Signal Transduction Phospholipase C-activating Adrenergic Receptor Signaling Pathway Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure MAPK Cascade Bradykinin Receptor Activity Regulation Of Dendritic Spine Development Septin Cytoskeleton Positive Regulation Of Dendritic Spine Development Cytoplasmic Pattern Recognition Receptor Signaling Pathway Guanylate Kinase-associated Protein Clustering Cyclic-di-GMP Binding STING Complex 2',3'-cyclic GMP-AMP Binding Pilomotor Reflex Alpha1-adrenergic Receptor Activity Positive Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Synapse Structural Plasticity Striatal Medium Spiny Neuron Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Neuron-glial Cell Signaling Positive Regulation Of Synaptic Transmission T Cell Antigen Processing And Presentation Toll-like Receptor 7 Signaling Pathway Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity NMDA Glutamate Receptor Clustering Positive Regulation Of Cardiac Muscle Contraction Signal Transduction Regulation Of Blood Pressure Regulation Of The Force Of Heart Contraction By Chemical Signal Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Action Potential Adrenergic Receptor Activity Mitochondrial Outer Membrane Innate Immune Response-activating Signaling Pathway Toll-like Receptor Binding Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Vocal Learning Neuron Spine Postsynaptic Density Assembly Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synapse Structural Plasticity Observational Learning Proton Channel Activity Positive Regulation Of CGAS/STING Signaling Pathway
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