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UCHL1 and TNFRSF1A
Number of citations of the paper that reports this interaction (PubMedID
24980434
)
49
Data Source:
BioGRID
(enzymatic study)
UCHL1
TNFRSF1A
Description
ubiquitin C-terminal hydrolase L1
TNF receptor superfamily member 1A
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Membrane
Axon
Neuronal Cell Body
Neuron Projection Terminus
Axon Cytoplasm
Golgi Membrane
Tumor Necrosis Factor Receptor Superfamily Complex
Extracellular Region
Extracellular Space
Golgi Apparatus
Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Membrane Raft
Molecular Function
Cysteine-type Endopeptidase Activity
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Omega Peptidase Activity
Hydrolase Activity
Signaling Receptor Inhibitor Activity
Ubiquitin Protein Ligase Binding
Alpha-2A Adrenergic Receptor Binding
Ribosome Binding
Ubiquitin Binding
Tumor Necrosis Factor Receptor Activity
Protein Binding
Signaling Receptor Activity
Tumor Necrosis Factor Binding
Biological Process
Male Germ Cell Proliferation
Response To Ischemia
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Axonogenesis
Axon Target Recognition
Adult Walking Behavior
Regulation Of Macroautophagy
Protein Deubiquitination
Axonal Transport Of Mitochondrion
Protein Catabolic Process
Eating Behavior
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of MAPK Cascade
Positive Regulation Of Glycolytic Process
Neuromuscular Process
Muscle Cell Development
Cellular Response To Xenobiotic Stimulus
Aortic Valve Development
Pulmonary Valve Development
Negative Regulation Of Extracellular Matrix Constituent Secretion
Transcription By RNA Polymerase II
Prostaglandin Metabolic Process
Apoptotic Process
Defense Response
Inflammatory Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cardiac Muscle Hypertrophy
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Amide Metabolic Process
Non-canonical NF-kappaB Signal Transduction
Defense Response To Bacterium
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Lipid Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Regulation Of Developmental Process
Regulation Of Multicellular Organismal Process
Cellular Response To Mechanical Stimulus
Protein Localization To Plasma Membrane
Apoptotic Signaling Pathway
Positive Regulation Of Execution Phase Of Apoptosis
Positive Regulation Of Apoptotic Process Involved In Morphogenesis
Regulation Of Establishment Of Endothelial Barrier
Regulation Of Membrane Lipid Metabolic Process
Pathways
UCH proteinases
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NF-kappa-B signaling pathway
TNFR1-mediated ceramide production
TNFs bind their physiological receptors
Interleukin-10 signaling
TNF signaling
Drugs
Phenethyl Isothiocyanate
6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Tasonermin
Diseases
Parkinson's disease (PD)
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS); Familial periodic fever
GWAS
Cognitive performance (
19734545
)
Metabolite levels (
23823483
)
Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) (
23648065
)
Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) (
23648065
)
Alopecia areata (
25608926
)
Ankylosing spondylitis (
23749187
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Colorectal cancer (
24836286
)
Crohn's disease (
26192919
)
Eosinophil count (
32888494
)
Lymphocyte count (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
27863252
)
Multiple sclerosis (
27386562
24076602
31604244
21833088
19525953
)
Neutrophil percentage of white cells (
32888494
)
Platelet count (
32888494
27863252
)
Plateletcrit (
27863252
32888494
)
Primary biliary cholangitis (
21399635
28425483
26394269
)
Primary biliary cirrhosis (
22961000
)
White blood cell count (
32888494
)
Interacting Genes
30 interacting genes:
ADRA2A
ADRA2B
ADRA2C
ADRB2
AKT1
CBX1
CDKN1B
COPS5
HSP90AA1
HSPA8
LAMP2
MYCBP2
NCAM1
NEDD8
PLA2G2A
RANBP9
RNF4
SHANK3
SMN1
TERF2IP
TINF2
TNFRSF1A
TRIM54
TRIM63
UBB
UBC
UBE2I
USP15
USP21
USP28
67 interacting genes:
ADAM17
AKT1
ATF6
BAG4
BCL10
CASP10
CASP7
CCND2
CDK6
CDKN2B
CHUK
CLIP3
CSNK1A1L
DAPK1
DAXX
EGFR
ERAP1
ERN1
FANCD2
GRB2
GYS2
HRG
HSP90AA1
HSPA8
IKBKB
IKBKG
JAK1
JAK2
LTA
LTB
MADD
MAGEH1
MAPK1
MOAP1
MYOC
NSMAF
PIP4K2B
PRDX3
PRKCD
PSMD2
PTK2
PTPN11
PTPN6
RACK1
RASSF1
RIPK1
RIPK2
RIPK3
SGTA
SRC
STAMBP
STAT1
STK11
SUMO1
SYK
TNF
TNFRSF25
TNFSF13
TRADD
TRAF1
TRAF2
TRAF3
TRAP1
TRPC4AP
UBE2I
UBQLN1
UCHL1
Entrez ID
7345
7132
HPRD ID
01877
01861
Ensembl ID
ENSG00000154277
ENSG00000067182
Uniprot IDs
P09936
V9HW74
J9PH39
P19438
PDB IDs
2ETL
2LEN
3IFW
3IRT
3KVF
3KW5
4DM9
4JKJ
7ZM0
8DY8
8EDE
8PW1
8XI7
1EXT
1FT4
1ICH
1NCF
1TNR
7K7A
7KP7
7KP8
7KPB
8P6Q
Enriched GO Terms of Interacting Partners
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Adrenergic Receptor Activity
Alpha2-adrenergic Receptor Activity
Post-translational Protein Modification
Nuclear Body
Adrenergic Receptor Signaling Pathway
Negative Regulation Of Epinephrine Secretion
Negative Regulation Of Norepinephrine Secretion
Epinephrine Binding
Chaperone-mediated Autophagy
Regulation Of Muscle System Process
Enzyme Binding
Regulation Of Norepinephrine Secretion
Negative Regulation Of Catecholamine Secretion
Positive Regulation Of Intracellular Signal Transduction
Protein Modification By Small Protein Conjugation
Regulation Of Intracellular Signal Transduction
Protein Tag Activity
Macromolecule Metabolic Process
Nucleoplasm
Regulation Of Smooth Muscle Contraction
Regulation Of System Process
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Protein Modification Process
ERBB Signaling Pathway
Regulation Of Signal Transduction
Regulation Of Muscle Contraction
Ubiquitin Protein Ligase Binding
Regulation Of Primary Metabolic Process
Norepinephrine Binding
Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy
Proteolysis
Regulation Of Organelle Organization
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Cellular Component Organization
Protein Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Catecholamine Secretion
DeNEDDylase Activity
Shelterin Complex
Macromolecule Catabolic Process
Protein Modification By Small Protein Removal
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Post-translational Protein Modification
Protein Ubiquitination
Response To Stress
Nitric-oxide Synthase Regulator Activity
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Apoptotic Process
Cytosol
Programmed Cell Death
Cell Death
Positive Regulation Of Signal Transduction
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Immune Response
Cytokine-mediated Signaling Pathway
Regulation Of Immune System Process
Tumor Necrosis Factor Receptor Binding
Regulation Of Defense Response
Positive Regulation Of Phosphate Metabolic Process
Positive Regulation Of Immune Response
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Metabolic Process
Signal Transduction
Response To Stress
Regulation Of Metabolic Process
Positive Regulation Of Catabolic Process
Cellular Response To Stress
Positive Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Ubiquitin Protein Ligase Binding
Protein Kinase Activity
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Modification Process
Regulation Of Apoptotic Signaling Pathway
Kinase Activity
Positive Regulation Of Apoptotic Process
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Programmed Cell Death
Regulation Of Protein Modification Process
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Protein Phosphorylation
Activation Of Immune Response
Immune Response-activating Signaling Pathway
Regulation Of Phosphorus Metabolic Process
Regulation Of Phosphorylation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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