TNFRSF1A and NSMAF

Number of citations of the paper that reports this interaction (PubMedID 8808629)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		TNFRSF1A	NSMAF
Description		TNF receptor superfamily member 1A	neutral sphingomyelinase activation associated factor
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Cell Surface Membrane Receptor Complex Membrane Raft	Cytoplasm Cytosol Membrane
	Molecular Function	Tumor Necrosis Factor Receptor Activity Protein Binding Signaling Receptor Activity Tumor Necrosis Factor Binding	Protein Binding
	Biological Process	Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Transcription By RNA Polymerase II Prostaglandin Metabolic Process Apoptotic Process Defense Response Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Amide Metabolic Process Non-canonical NF-kappaB Signal Transduction Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Lipid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of Establishment Of Endothelial Barrier Regulation Of Membrane Lipid Metabolic Process	Ceramide Metabolic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Amide Metabolic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Membrane Lipid Metabolic Process
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway TNFR1-mediated ceramide production TNFs bind their physiological receptors Interleukin-10 signaling TNF signaling	TNFR1-mediated ceramide production
Drugs		6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One Tasonermin
Diseases		Tumor necrosis factor receptor-associated periodic syndrome (TRAPS); Familial periodic fever
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Alopecia areata ( 25608926) Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 24836286) Crohn's disease ( 26192919) Eosinophil count ( 32888494) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494 27863252) Multiple sclerosis ( 27386562 24076602 31604244 21833088 19525953) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252 32888494) Primary biliary cholangitis ( 21399635 28425483 26394269) Primary biliary cirrhosis ( 22961000) White blood cell count ( 32888494)	Basophil count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483)
Interacting Genes		67 interacting genes: ADAM17 AKT1 ATF6 BAG4 BCL10 CASP10 CASP7 CCND2 CDK6 CDKN2B CHUK CLIP3 CSNK1A1L DAPK1 DAXX EGFR ERAP1 ERN1 FANCD2 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RACK1 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 STK11 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1	6 interacting genes: ACTB CD40 DCP1A DCP1B RACK1 TNFRSF1A
Entrez ID		7132	8439
HPRD ID		01861	09117
Ensembl ID		ENSG00000067182	ENSG00000035681
Uniprot IDs		J9PH39 P19438	Q92636
PDB IDs		1EXT 1FT4 1ICH 1NCF 1TNR 7K7A 7KP7 7KP8 7KPB 8P6Q
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Apoptotic Process Cytosol Programmed Cell Death Cell Death Positive Regulation Of Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Cytokine-mediated Signaling Pathway Regulation Of Immune System Process Tumor Necrosis Factor Receptor Binding Regulation Of Defense Response Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Signal Transduction Response To Stress Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Cellular Response To Stress Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Protein Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Apoptotic Signaling Pathway Kinase Activity Positive Regulation Of Apoptotic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Protein Modification Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Activation Of Immune Response Immune Response-activating Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation	Enzyme Activator Activity Deadenylation-independent Decapping Of Nuclear-transcribed MRNA 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Methylguanosine-cap Decapping RNA Decapping Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Kinesin Binding Positive Regulation Of DNA Recombination Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Cellular Response To Mechanical Stimulus Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Protein Localization To Plasma Membrane Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Development Positive Regulation Of Developmental Process Regulation Of Gene Expression Regulation Of Norepinephrine Uptake Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting P-body Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Regulation Of DNA Recombination Regulation Of Macromolecule Metabolic Process Transporter Regulator Activity Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Response To Cobalamin Regulation Of Protein Localization To Cell Periphery Regulation Of Transepithelial Transport Cellular Response To Erythropoietin Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Protein Localization To Membrane Protein Localization To Adherens Junction Regulation Of Metabolic Process Dense Body Regulation Of Protein Kinase C Signaling Response To Erythropoietin Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Translational Elongation
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