UCHL1

Description		ubiquitin C-terminal hydrolase L1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Axon Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Omega Peptidase Activity Hydrolase Activity Signaling Receptor Inhibitor Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ribosome Binding Ubiquitin Binding
	Biological Process	Male Germ Cell Proliferation Response To Ischemia Proteolysis Ubiquitin-dependent Protein Catabolic Process Axonogenesis Axon Target Recognition Adult Walking Behavior Regulation Of Macroautophagy Protein Deubiquitination Axonal Transport Of Mitochondrion Protein Catabolic Process Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAPK Cascade Positive Regulation Of Glycolytic Process Neuromuscular Process Muscle Cell Development Cellular Response To Xenobiotic Stimulus
Pathways		UCH proteinases
Drugs		Phenethyl Isothiocyanate
Diseases		Parkinson's disease (PD)
GWAS		Cognitive performance ( 19734545) Metabolite levels ( 23823483)
Novel Interacting Genes		30 novel interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 HSP90AA1 HSPA8 LAMP2 MYCBP2 NCAM1 NEDD8 PLA2G2A RANBP9 RNF4 SHANK3 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBB UBC UBE2I USP15 USP21 USP28
Interacting Genes		30 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 HSP90AA1 HSPA8 LAMP2 MYCBP2 NCAM1 NEDD8 PLA2G2A RANBP9 RNF4 SHANK3 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBB UBC UBE2I USP15 USP21 USP28
Entrez ID		7345
HPRD ID		01877
Ensembl ID		ENSG00000154277
Uniprot IDs		P09936 V9HW74
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ 7ZM0 8DY8 8EDE 8PW1 8XI7
Enriched GO Terms of Interacting Partners?		Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Post-translational Protein Modification Nuclear Body Adrenergic Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Chaperone-mediated Autophagy Regulation Of Muscle System Process Enzyme Binding Regulation Of Norepinephrine Secretion Negative Regulation Of Catecholamine Secretion Positive Regulation Of Intracellular Signal Transduction Protein Modification By Small Protein Conjugation Regulation Of Intracellular Signal Transduction Protein Tag Activity Macromolecule Metabolic Process Nucleoplasm Regulation Of Smooth Muscle Contraction Regulation Of System Process Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Signal Transduction Protein Modification Process ERBB Signaling Pathway Regulation Of Signal Transduction Regulation Of Muscle Contraction Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Norepinephrine Binding Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Proteolysis Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cellular Component Organization Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Catecholamine Secretion DeNEDDylase Activity Shelterin Complex Macromolecule Catabolic Process Protein Modification By Small Protein Removal Regulation Of Signaling Regulation Of Cell Communication Regulation Of Post-translational Protein Modification Protein Ubiquitination Response To Stress Nitric-oxide Synthase Regulator Activity
Tagcloud ?