TOP3A and TDRD3

Number of citations of the paper that reports this interaction (PubMedID 28176834)
50

Data Source:
BioGRID (x-ray crystallography, pull down)

		TOP3A	TDRD3
Description		DNA topoisomerase III alpha	tudor domain containing 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Mitochondrion Mitochondrial Matrix PML Body RecQ Family Helicase-topoisomerase III Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Exon-exon Junction Complex DNA Topoisomerase III-beta-TDRD3 Complex
	Molecular Function	DNA Binding Single-stranded DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Zinc Ion Binding Isomerase Activity Metal Ion Binding	Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding Histone H3 Reader Activity Histone H4 Reader Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Topological Change DNA Repair DNA Recombination Mitochondrial DNA Metabolic Process Chromosome Separation Meiotic Cell Cycle Resolution Of DNA Recombination Intermediates	DNA Topological Change Chromatin Organization Positive Regulation Of DNA-templated Transcription
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases
GWAS		Systolic blood pressure ( 30224653)	Breast size ( 22747683) Menopause (age at onset) ( 22267201 26414677) Verbal declarative memory ( 25648963)
Interacting Genes		3 interacting genes: BLM RECQL5 TDRD3	7 interacting genes: FUS H3-4 POLR2A TOP3A TOP3B UBC USP9X
Entrez ID		7156	81550
HPRD ID		03145	11625
Ensembl ID		ENSG00000177302	ENSG00000083544
Uniprot IDs		Q13472	Q9H7E2
PDB IDs		4CGY 4CHT	1WJI 2LTO 3PMT 3PNW 3S6W 5GVD 5GVE 5YJ8 6V9T 8JTN 9C9W 9C9Y 9CA0 9CA1 9CA4 9CAG 9CAH 9CAJ 9CAK 9CAL
Enriched GO Terms of Interacting Partners?		Four-way Junction Helicase Activity Cellular Response To Camptothecin 3'-5' DNA Helicase Activity DNA Conformation Change Replication Fork Cellular Response To Alkaloid DNA Helicase Activity Negative Regulation Of DNA Recombination Response To Alkaloid DNA Metabolic Process Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Recombinational Repair Helicase Activity Double-strand Break Repair Via Homologous Recombination DNA Replication Isomerase Activity Forked DNA-dependent Helicase Activity Mitotic DNA-templated DNA Replication Histone H3 Reader Activity DNA Topoisomerase III-beta-TDRD3 Complex 8-hydroxy-2'-deoxyguanosine DNA Binding Double-strand Break Repair Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity Mitotic DNA Replication DNA Recombination RecQ Family Helicase-topoisomerase III Complex Telomeric D-loop Binding Response To Alcohol Y-form DNA Binding Catalytic Activity, Acting On DNA Histone H4 Reader Activity Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Nuclear DNA Replication Chromosome Organization Telomere Maintenance Via Semi-conservative Replication DNA Geometric Change ATP Hydrolysis Activity Bubble DNA Binding Resolution Of DNA Recombination Intermediates Telomeric D-loop Disassembly G-quadruplex DNA Binding Nucleic Acid Metabolic Process DNA Topological Change Cellular Response To Hydroxyurea Telomeric Loop Disassembly Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Chromosome Separation T-circle Formation	DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity DNA Topoisomerase Activity DNA Topological Change DNA Conformation Change Amyloid Fibril Formation K11-linked Deubiquitinase Activity RNA Topoisomerase Activity DNA Binding DNA Repair DNA Topoisomerase III-beta-TDRD3 Complex Nucleus RNA-directed RNA Polymerase Activity RNA-templated Transcription RNA Binding RecQ Family Helicase-topoisomerase III Complex Isomerase Activity Chromosome Segregation Spermatogonial Cell Division Regulation Of RNA Splicing Chromosome Microfibril Binding DNA Metabolic Process Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cytosolic Ciliogenesis Macromolecule Metabolic Process 5'-3' RNA Polymerase Activity DNA Damage Response DNA Replication-dependent Chromatin Assembly Positive Regulation Of TORC2 Signaling DNA Recombination Resolution Of DNA Recombination Intermediates Positive Regulation Of Protein Binding Monoubiquitinated Protein Deubiquitination Protein Import Into Peroxisome Matrix, Receptor Recycling Chromosome Separation DNA Alkylation Repair Nucleic Acid Metabolic Process Co-SMAD Binding Regulation Of TORC2 Signaling Prp19 Complex Protein Import Into Peroxisome Matrix Ubiquitin Protein Ligase Binding Protein Tag Activity RNA Polymerase II, Core Complex Molecular Sequestering Activity K63-linked Deubiquitinase Activity
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