TOP3A

Description		DNA topoisomerase III alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Mitochondrion Mitochondrial Matrix PML Body RecQ Family Helicase-topoisomerase III Complex
	Molecular Function	DNA Binding Single-stranded DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Zinc Ion Binding Isomerase Activity Metal Ion Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Topological Change DNA Repair DNA Recombination Mitochondrial DNA Metabolic Process Chromosome Separation Meiotic Cell Cycle Resolution Of DNA Recombination Intermediates
Pathways		HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2 Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases
GWAS		Systolic blood pressure ( 30224653)
Novel Interacting Genes		3 novel interacting genes: BLM RECQL5 TDRD3
Interacting Genes		3 interacting genes: BLM RECQL5 TDRD3
Entrez ID		7156
HPRD ID		03145
Ensembl ID		ENSG00000177302
Uniprot IDs		Q13472
PDB IDs		4CGY 4CHT
Enriched GO Terms of Interacting Partners?		Four-way Junction Helicase Activity Cellular Response To Camptothecin 3'-5' DNA Helicase Activity DNA Conformation Change Replication Fork Cellular Response To Alkaloid DNA Helicase Activity Negative Regulation Of DNA Recombination Response To Alkaloid DNA Metabolic Process Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Recombinational Repair Helicase Activity Double-strand Break Repair Via Homologous Recombination DNA Replication Isomerase Activity Forked DNA-dependent Helicase Activity Mitotic DNA-templated DNA Replication Histone H3 Reader Activity DNA Topoisomerase III-beta-TDRD3 Complex 8-hydroxy-2'-deoxyguanosine DNA Binding Double-strand Break Repair Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity Mitotic DNA Replication DNA Recombination RecQ Family Helicase-topoisomerase III Complex Telomeric D-loop Binding Response To Alcohol Y-form DNA Binding Catalytic Activity, Acting On DNA Histone H4 Reader Activity Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Nuclear DNA Replication Chromosome Organization Telomere Maintenance Via Semi-conservative Replication DNA Geometric Change ATP Hydrolysis Activity Bubble DNA Binding Resolution Of DNA Recombination Intermediates Telomeric D-loop Disassembly G-quadruplex DNA Binding Nucleic Acid Metabolic Process DNA Topological Change Cellular Response To Hydroxyurea Telomeric Loop Disassembly Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Chromosome Separation T-circle Formation
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