TLR3 and MAP2K6

Number of citations of the paper that reports this interaction (PubMedID 12609980)
0

Data Source:
BioGRID (enzymatic study)

		TLR3	MAP2K6
Description		toll like receptor 3	mitogen-activated protein kinase kinase 6
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Endosome Membrane Membrane Endolysosome Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton
	Molecular Function	RNA Binding Double-stranded RNA Binding Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Ubiquitin-like Protein Ligase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Microglial Cell Activation Toll-like Receptor Signaling Pathway Immune System Process Positive Regulation Of Immune System Process Regulation Of Dendritic Cell Cytokine Production Defense Response Inflammatory Response Hyperosmotic Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Male Gonad Development Detection Of Virus Response To Virus Positive Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Type III Interferon Production Positive Regulation Of Type III Interferon Production Cellular Response To Interferon-beta Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Exogenous DsRNA Response To DsRNA Innate Immune Response Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Inflammatory Response Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Cellular Response To Exogenous DsRNA Cellular Response To Xenobiotic Stimulus Inflammatory Response To Wounding Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Cellular Response To Virus Intracellular Signaling Cassette Positive Regulation Of Cytokine Production Involved In Inflammatory Response	MAPK Cascade Osteoblast Differentiation Apoptotic Process Signal Transduction Stress-activated Protein Kinase Signaling Cascade Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway P38MAPK Cascade Signal Transduction In Response To DNA Damage Positive Regulation Of MAPK Cascade Stress-activated MAPK Cascade Protein Maturation Regulation Of Cell Cycle Cardiac Muscle Contraction Bone Development Pyroptotic Inflammatory Response Cellular Response To UV-B Cellular Senescence Negative Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly
Pathways		Trafficking and processing of endosomal TLR Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TLR3 deficiency - HSE UNC93B1 deficiency - HSE TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation RSV-host interactions	NOD1/2 Signaling Pathway Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation Myogenesis PI5P Regulates TP53 Acetylation Interleukin-1 signaling PKR-mediated signaling
Drugs			Fostamatinib Pimasertib
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Breast size ( 22747683) Medication use (thyroid preparations) ( 31015401)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Optic disc size ( 31809533) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Waist-hip ratio ( 28552196)
Interacting Genes		13 interacting genes: CD14 CFTR CHEK2 CSK HLA-DRA IRGM MAP2K6 MYD88 RNF10 RNF216 TICAM1 TICAM2 TRAF6	39 interacting genes: AKT1 BECN1 BRAF CCND2 CDKN2B DCTN1 EIF2AK2 EPHA2 FBXO7 FGFR4 GLIS2 HGF HRAS LRRK2 MAP2K4 MAP2K5 MAP3K20 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 NFE2L2 PICK1 PKN1 PLCB2 RAF1 RASSF1 RELA SMAD7 STAT4 STK11 TAOK2 TLR3 TRAF6
Entrez ID		7098	5608
HPRD ID		04324	03155
Ensembl ID		ENSG00000164342	ENSG00000108984
Uniprot IDs		O15455	A8K3Y2 P52564
PDB IDs		1ZIW 2A0Z 2MK9 2MKA 3ULU 3ULV 5GS0 7C76 7WV3 7WV4 7WV5 7WVE 7WVF 7WVJ 8AR1 8YHT 8YHU 9LSH 9LSI 9LSJ	2Y8O 3ENM 3FME 3VN9 5ETF 8A8M 8P7J 8PM3
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Immune Response Cell Surface Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Cellular Response To Lipopolysaccharide Regulation Of Immune Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Lipid Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Defense Response Endosome Membrane Toll-like Receptor Signaling Pathway Response To Lipopolysaccharide TRIF-dependent Toll-like Receptor Signaling Pathway Response To Molecule Of Bacterial Origin MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Immune System Process Signaling Adaptor Activity Positive Regulation Of Multicellular Organismal Process Intracellular Receptor Signaling Pathway Immune Response Response To Lipid Endolysosomal Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Lymphocyte Activation Innate Immune Response Regulation Of Cell Activation	MAPK Cascade Intracellular Signal Transduction Protein Serine Kinase Activity Protein Kinase Activity Intracellular Signaling Cassette Protein Serine/threonine Kinase Activity Kinase Activity MAP Kinase Kinase Kinase Activity Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stress ATP Binding Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Stress-activated MAPK Cascade Nucleotide Binding P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Macromolecule Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Response To Cytokine Protein Phosphorylation Response To Peptide Positive Regulation Of MAPK Cascade Phosphorylation JNK Cascade Immune Response-regulating Signaling Pathway Response To Growth Factor Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling MAP Kinase Activity Regulation Of Immune System Process Immune Response-activating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process Cell Death
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