TLR3 and TICAM1

Number of citations of the paper that reports this interaction (PubMedID 14982987)
43

Data Source:
HPRD (two hybrid, in vivo)

		TLR3	TICAM1
Description		toll like receptor 3	TIR domain containing adaptor molecule 1
Image
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosomal Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Cell Surface Endosome Membrane Membrane Endolysosome Membrane	Cytoplasm Mitochondrion Endosome Early Endosome Autophagosome Cytosol Endosome Membrane Cytoplasmic Vesicle Ripoptosome
	Molecular Function	RNA Binding Double-stranded RNA Binding Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Ubiquitin-like Protein Ligase Binding	Protein Binding Protein Kinase Binding Signaling Adaptor Activity Molecular Adaptor Activity
	Biological Process	MAPK Cascade Microglial Cell Activation Toll-like Receptor Signaling Pathway Immune System Process Positive Regulation Of Immune System Process Regulation Of Dendritic Cell Cytokine Production Defense Response Inflammatory Response Hyperosmotic Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Male Gonad Development Detection Of Virus Response To Virus Positive Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 3 Signaling Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Type III Interferon Production Positive Regulation Of Type III Interferon Production Cellular Response To Interferon-beta Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Exogenous DsRNA Response To DsRNA Innate Immune Response Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Inflammatory Response Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Cellular Response To Mechanical Stimulus Cellular Response To Type II Interferon Cellular Response To Exogenous DsRNA Cellular Response To Xenobiotic Stimulus Inflammatory Response To Wounding Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Cellular Response To Virus Intracellular Signaling Cassette Positive Regulation Of Cytokine Production Involved In Inflammatory Response	Toll-like Receptor Signaling Pathway Macrophage Activation Involved In Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production MyD88-independent Toll-like Receptor Signaling Pathway Nitric Oxide Biosynthetic Process Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway B Cell Proliferation B Cell Activation Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of B Cell Activation Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Cellular Response To Lipopolysaccharide Apoptotic Signaling Pathway Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Trafficking and processing of endosomal TLR Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TLR3 deficiency - HSE UNC93B1 deficiency - HSE TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation RSV-host interactions	Caspase activation via Death Receptors in the presence of ligand MyD88-independent TLR4 cascade Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Breast size ( 22747683) Medication use (thyroid preparations) ( 31015401)	Basal cell carcinoma ( 33549134) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 22561518 27723757)
Interacting Genes		13 interacting genes: CD14 CFTR CHEK2 CSK HLA-DRA IRGM MAP2K6 MYD88 RNF10 RNF216 TICAM1 TICAM2 TRAF6	25 interacting genes: AZI2 IKBKE IRF3 IRF7 MAVS PIAS4 PIK3CA RIPK1 RIPK3 SRSF4 TBK1 TICAM2 TIRAP TLR2 TLR3 TNFAIP3 TRAF1 TRAF2 TRAF3 TRAF4 TRAF6 TRAM1 TRIM8 UBQLN1 WWP2
Entrez ID		7098	148022
HPRD ID		04324	06350
Ensembl ID		ENSG00000164342	ENSG00000127666
Uniprot IDs		O15455	Q8IUC6
PDB IDs		1ZIW 2A0Z 2MK9 2MKA 3ULU 3ULV 5GS0 7C76 7WV3 7WV4 7WV5 7WVE 7WVF 7WVJ 8AR1 8YHT 8YHU 9LSH 9LSI 9LSJ	2M1X 2M63 3RC4 4BSX 4C0M 5JEL 9DK8
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Immune Response Cell Surface Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Cellular Response To Lipopolysaccharide Regulation Of Immune Response Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Lipid Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Defense Response Endosome Membrane Toll-like Receptor Signaling Pathway Response To Lipopolysaccharide TRIF-dependent Toll-like Receptor Signaling Pathway Response To Molecule Of Bacterial Origin MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Immune System Process Signaling Adaptor Activity Positive Regulation Of Multicellular Organismal Process Intracellular Receptor Signaling Pathway Immune Response Response To Lipid Endolysosomal Toll-like Receptor Signaling Pathway Immune System Process Inflammatory Response Regulation Of Toll-like Receptor 4 Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Lymphocyte Activation Innate Immune Response Regulation Of Cell Activation	Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Innate Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Signaling Adaptor Activity Defense Response To Virus Defense Response Positive Regulation Of Innate Immune Response Activation Of Immune Response Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Defense Response Regulation Of Interferon-beta Production Regulation Of Cell Communication Regulation Of Signaling Immune Response-activating Signaling Pathway Positive Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Cytokine Production Response To External Biotic Stimulus Positive Regulation Of Signal Transduction Response To Virus Response To Stress Response To Other Organism Immune Response-regulating Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Type I Interferon-mediated Signaling Pathway Innate Immune Response Regulation Of Defense Response Cell Surface Pattern Recognition Receptor Signaling Pathway Immune System Process Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Defense Response To Symbiont Interferon-mediated Signaling Pathway Identical Protein Binding
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