MAP2K6 and PKN1

Number of citations of the paper that reports this interaction (PubMedID 12761180)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		MAP2K6	PKN1
Description		mitogen-activated protein kinase kinase 6	protein kinase N1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Protein-containing Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Identical Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Small GTPase Binding Histone H3T11 Kinase Activity Histone Binding Histone Deacetylase Binding Nuclear Androgen Receptor Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Osteoblast Differentiation Apoptotic Process Signal Transduction Stress-activated Protein Kinase Signaling Cascade Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway P38MAPK Cascade Signal Transduction In Response To DNA Damage Positive Regulation Of MAPK Cascade Stress-activated MAPK Cascade Protein Maturation Regulation Of Cell Cycle Cardiac Muscle Contraction Bone Development Pyroptotic Inflammatory Response Cellular Response To UV-B Cellular Senescence Negative Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly	B Cell Homeostasis B Cell Apoptotic Process Regulation Of Germinal Center Formation Regulation Of Immunoglobulin Production Renal System Process Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hyperosmotic Response Signal Transduction Epithelial Cell Migration Negative Regulation Of B Cell Proliferation Intracellular Signal Transduction Post-translational Protein Modification Positive Regulation Of DNA-templated Transcription Spleen Development Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Motility
Pathways		NOD1/2 Signaling Pathway Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation Myogenesis PI5P Regulates TP53 Acetylation Interleukin-1 signaling PKR-mediated signaling	RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle
Drugs		Fostamatinib Pimasertib	Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Appendicular lean mass ( 33097823) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Optic disc size ( 31809533) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Waist-hip ratio ( 28552196)	Pancreatic cancer ( 30206226) Urolithiasis ( 30975718)
Interacting Genes		39 interacting genes: AKT1 BECN1 BRAF CCND2 CDKN2B DCTN1 EIF2AK2 EPHA2 FBXO7 FGFR4 GLIS2 HGF HRAS LRRK2 MAP2K4 MAP2K5 MAP3K20 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 NFE2L2 PICK1 PKN1 PLCB2 RAF1 RASSF1 RELA SMAD7 STAT4 STK11 TAOK2 TLR3 TRAF6	83 interacting genes: ACTN1 ADAMTSL4 AKAP9 ARHGAP10 ARHGAP26 ARSA BLZF1 BUD23 CASP3 CCDC136 CCDC138 CCDC85B CCNT2 CD44 CDC25C CDR2 CEP57 CEP57L1 CEP70 CYSRT1 DISC1 DNAAF19 DYDC1 EIF3F GOLGA2 GOLGA6L9 H3C14 HAP1 HAUS1 HDAC5 HOMER3 HSF2BP INTS11 KIAA1328 KRT15 KRT16 KRT19 KRT31 KRT34 KRT35 KRT36 KRT37 LRRC61 MAP2K6 MAPK12 MAPT MARCKS MBP MID1 MID2 MIPOL1 MKRN3 MTDH MTUS2 NEFH NEFL NEUROD2 PDPK1 PICK1 PLD1 PNMA1 POU6F2 PSMB4 RAB3IP RHOA RHOB SERTAD3 SMYD3 SPAG5 SPRR2D SSX2IP STX11 SYCE3 TNFRSF1B TRAF1 TRAF2 TSGA10 UBR2 USHBP1 VIM ZFAND6 ZNF282 ZRANB1
Entrez ID		5608	5585
HPRD ID		03155	03019
Ensembl ID		ENSG00000108984	ENSG00000123143
Uniprot IDs		A8K3Y2 P52564	Q16512
PDB IDs		2Y8O 3ENM 3FME 3VN9 5ETF 8A8M 8P7J 8PM3	1CXZ 1URF 2RMK 4NKG 4OTD 4OTG 4OTH 4OTI
Enriched GO Terms of Interacting Partners?		MAPK Cascade Intracellular Signal Transduction Protein Serine Kinase Activity Protein Kinase Activity Intracellular Signaling Cassette Protein Serine/threonine Kinase Activity Kinase Activity MAP Kinase Kinase Kinase Activity Signal Transduction Regulation Of Intracellular Signal Transduction Cellular Response To Stress ATP Binding Regulation Of Signal Transduction Response To Stress Regulation Of Cell Communication Regulation Of Signaling Stress-activated MAPK Cascade Nucleotide Binding P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Transferase Activity Positive Regulation Of Macromolecule Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Response To Cytokine Protein Phosphorylation Response To Peptide Positive Regulation Of MAPK Cascade Phosphorylation JNK Cascade Immune Response-regulating Signaling Pathway Response To Growth Factor Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling MAP Kinase Activity Regulation Of Immune System Process Immune Response-activating Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Biosynthetic Process Cell Death	Cytoskeleton Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cytoskeleton Organization Intermediate Filament Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Organelle Organization Keratin Filament Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Cytosol Identical Protein Binding Structural Molecule Activity Protein Binding Tissue Morphogenesis Microtubule Binding Regulation Of Microtubule-based Process Microtubule Cytoplasm Regulation Of Microtubule Cytoskeleton Organization Centrosome Epithelial Cell Differentiation Developmental Process Microtubule Cytoskeleton Organization Epidermis Development Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton Postsynaptic Intermediate Filament Cytoskeleton Organization Neurofilament Bundle Assembly Protein Localization To Cytoskeleton Intermediate Filament Cytoskeleton Cellular Component Assembly Microtubule-based Process Postsynaptic Intermediate Filament Cytoskeleton Tumor Necrosis Factor Receptor Superfamily Complex Cellular Developmental Process Axon Development Neurofibrillary Tangle Regulation Of Synapse Maturation Tumor Necrosis Factor Binding Gamma-tubulin Binding Intermediate Filament Bundle Assembly Cell Projection Organization Regulation Of Organelle Transport Along Microtubule Response To Electrical Stimulus Regulation Of Canonical NF-kappaB Signal Transduction Neurofilament Cytoskeleton Organization Thioesterase Binding Focal Adhesion
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