TH and RPS6KA5

Number of citations of the paper that reports this interaction (PubMedID 12421349)
0

Data Source:
HPRD (in vivo, in vitro)

		TH	RPS6KA5
Description		tyrosine hydroxylase	ribosomal protein S6 kinase A5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Axon Cytoplasmic Vesicle Melanosome Membrane Cell Projection Neuron Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Monooxygenase Activity Tyrosine 3-monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Identical Protein Binding Metal Ion Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone H3S10 Kinase Activity Histone H3S28 Kinase Activity Histone H2AS1 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Response To Hypoxia Synaptic Transmission, Dopaminergic Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Heart Development Visual Perception Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Aromatic Amino Acid Metabolic Process Anatomical Structure Morphogenesis Animal Organ Morphogenesis Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Serotonin Biosynthetic Process Eye Photoreceptor Cell Development Eating Behavior Pigmentation Response To Ethanol Embryonic Camera-type Eye Morphogenesis Cognition Hyaloid Vascular Plexus Regression	Negative Regulation Of Cytokine Production Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Phosphorylation Inflammatory Response Axon Guidance Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction TORC1 Signaling Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Regulation Of Postsynapse Organization
Pathways		Catecholamine biosynthesis	ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling
Drugs		Phenylalanine Tyrosine Sapropterin Metyrosine 3-Tyrosine L-erythro-7,8-dihydrobiopterin
Diseases		Primary torsion dystonia (PTD)
GWAS		Celiac disease ( 23936387) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Prostate cancer ( 19767753) Prostate cancer (early onset) ( 24740154) Prostate cancer (SNP x SNP interaction) ( 22219177) Severe autoimmune type 2 diabetes ( 34737425) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 25102180 31324766)	A body shape index ( 34021172) Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Femoral neck bone mineral density ( 22504420 29499414) Fractures ( 30158200) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 29499414) Multiple sclerosis ( 31604244) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		31 interacting genes: CAMK2G CDK11B CRABP1 CSNK2A1 DAAM2 GAD1 HLA-G HNRNPK MAPK1 MAPK3 MAPKAPK2 MDFI NPAS1 PHLDA2 PIAS2 PRKACA PUF60 RBMY1A1 RNH1 RPS6KA5 SHC1 SNCA STIM1 TNNI2 TRIM21 TSPYL4 TYSND1 UMAD1 YWHAB YWHAZ ZNF569	60 interacting genes: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CRYAA CTNNA3 DDAH2 DNAJC11 EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 H1-1 H1-5 H2AC25 H2BC21 H2BC26 H2BC3 H3-4 H3C14 H3C6 H4C14 H4C16 HMGN1 HSPB2 IL17RB ITSN1 MAP3K20 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZNF775
Entrez ID		7054	9252
HPRD ID		01865	06789
Ensembl ID		ENSG00000180176	ENSG00000100784
Uniprot IDs		P07101 P78428	O75582
PDB IDs		2XSN 4J6S 6ZN2 6ZVP 6ZZU 7A2G 7PIM	1VZO 3KN5 3KN6 7UP4 7UP5 7UP6 7UP7 7UP8
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Serine Kinase Activity Regulation Of Primary Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Kinase Activity TORC1 Signaling Interleukin-34-mediated Signaling Pathway Kinase Activity Negative Regulation Of Macromolecule Metabolic Process TOR Signaling Regulation Of Golgi Inheritance Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein Phosphorylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Protein Stability Phosphoserine Residue Binding Protein Domain Specific Binding Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Multicellular Organismal Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of MRNA Processing Focal Adhesion Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Long-term Synaptic Potentiation Nucleus ERK1 And ERK2 Cascade Bergmann Glial Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Epinephrine Stimulus	Structural Constituent Of Chromatin Nucleosome Nucleosome Organization Chromatin Organization DNA Binding Response To Light Stimulus Protein Heterodimerization Activity Response To UV Response To UV-B Nucleosome Assembly Nucleus Chromatin Remodeling Protein-containing Complex Assembly Chromatin DNA Binding Protein-containing Complex Organization Protein-DNA Complex Assembly Regulation Of Cell Development Response To Radiation Chromatin Cellular Response To UV Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Cellular Response To UV-B Regulation Of Cell Differentiation Transcription Regulator Complex Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Nucleoplasm Double-stranded DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Stress Positive Regulation Of Multicellular Organismal Process Sequence-specific DNA Binding Chromosome Cellular Component Assembly Chromatin Binding Regulation Of Developmental Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Development Regulation Of Myeloid Cell Differentiation Transcription Coactivator Binding Intracellular Signaling Cassette Positive Regulation Of Cytokine Production Intracellular Signal Transduction
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