RPS6KA5 and ROBO2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		RPS6KA5	ROBO2
Description		ribosomal protein S6 kinase A5	roundabout guidance receptor 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Plasma Membrane Cell Surface Membrane Axolemma Extracellular Exosome
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Histone H3S10 Kinase Activity Histone H3S28 Kinase Activity Histone H2AS1 Kinase Activity Metal Ion Binding Protein Serine Kinase Activity	Protein Binding Axon Guidance Receptor Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Chromatin Remodeling Regulation Of DNA-templated Transcription Protein Phosphorylation Inflammatory Response Axon Guidance Positive Regulation Of CREB Transcription Factor Activity Intracellular Signal Transduction TORC1 Signaling Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-1-mediated Signaling Pathway Regulation Of Postsynapse Organization	Metanephros Development Ureteric Bud Development Heart Induction Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Central Nervous System Development Brain Development Axon Midline Choice Point Recognition Olfactory Bulb Interneuron Development Cell Differentiation Retinal Ganglion Cell Axon Guidance Cellular Response To Hormone Stimulus Tube Development Aorta Development Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Negative Regulation Of Synapse Assembly Ventricular Septum Morphogenesis Apoptotic Process Involved In Luteolysis Cell-cell Adhesion
Pathways		ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling	Signaling by ROBO receptors Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs ROBO receptors bind AKAP5 Formation of the ureteric bud
Drugs
Diseases			Vesicoureteral reflux
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Bitter alcoholic beverage consumption ( 31046077) Femoral neck bone mineral density ( 22504420 29499414) Fractures ( 30158200) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 29499414) Multiple sclerosis ( 31604244) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bell's palsy ( 33602968) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Body size at age 10 ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Expressive vocabulary in infants ( 25226531) Familial lung adenocarcinoma ( 29924316) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hand grip strength ( 29691431) Hip circumference ( 28552196) LDL cholesterol levels in HIV infection ( 33109212) Left-handedness ( 32989287) Metabolite levels ( 23823483) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Morning person ( 30696823) Periodontitis (PAL4Q3) ( 24024966) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to ketamine in bipolar disorder or major depression (dissociation effects) ( 30552317) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30297969)
Interacting Genes		60 interacting genes: ACTG1 AKT1S1 ALG8 APP ATF1 ATF2 BAD CEBPB CREB1 CREBBP CRMP1 CRYAA CTNNA3 DDAH2 DNAJC11 EIF4EBP1 EP300 ERH ETV1 EZH2 FN1 GPRASP2 H1-1 H1-5 H2AC25 H2BC21 H2BC26 H2BC3 H3-4 H3C14 H3C6 H4C14 H4C16 HMGN1 HSPB2 IL17RB ITSN1 MAP3K20 MAPK11 MAPK14 MAPT MBP MDFIC NR4A1 PDLIM1 PLA2G4A RAI1 RELA RNF19A ROBO2 RPA1 SMAD6 SMARCB1 STAT1 STAT3 STK11 TH TXNDC11 UNC119 ZNF775	18 interacting genes: BNIP3L CENPU CPE GPR152 HLA-DPB1 NR1H2 NR4A1 OLFM2 PPP1R1B RDH11 ROBO1 RPS6KA5 SLIT2 SLIT3 SSRP1 TMEM237 TRIM13 UBQLN4
Entrez ID		9252	6092
HPRD ID		06789	11895
Ensembl ID		ENSG00000100784	ENSG00000185008
Uniprot IDs		O75582	A0A8Q3SIU0 A0A8Q3SIW8 A0A8Q3WLE3 A0A994J7I9 F8W703 H7C4J7 H7C4U9 H7C4W9 Q9HCK4
PDB IDs		1VZO 3KN5 3KN6 7UP4 7UP5 7UP6 7UP7 7UP8	1UEM 1UJT 2EDJ 5NOI 6I9S 6IAA
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Chromatin Nucleosome Nucleosome Organization Chromatin Organization DNA Binding Response To Light Stimulus Protein Heterodimerization Activity Response To UV Response To UV-B Nucleosome Assembly Nucleus Chromatin Remodeling Protein-containing Complex Assembly Chromatin DNA Binding Protein-containing Complex Organization Protein-DNA Complex Assembly Regulation Of Cell Development Response To Radiation Chromatin Cellular Response To UV Positive Regulation Of Cell Differentiation Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Light Stimulus Regulation Of Macromolecule Metabolic Process Cellular Response To UV-B Regulation Of Cell Differentiation Transcription Regulator Complex Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Nucleoplasm Double-stranded DNA Binding Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Stress Positive Regulation Of Multicellular Organismal Process Sequence-specific DNA Binding Chromosome Cellular Component Assembly Chromatin Binding Regulation Of Developmental Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Development Regulation Of Myeloid Cell Differentiation Transcription Coactivator Binding Intracellular Signaling Cassette Positive Regulation Of Cytokine Production Intracellular Signal Transduction	Roundabout Signaling Pathway Negative Regulation Of Chemokine-mediated Signaling Pathway Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Chemorepulsion Involved In Embryonic Olfactory Bulb Interneuron Precursor Migration Apoptotic Process Involved In Luteolysis Blood Vessel Endothelial Cell Migration Aortic Valve Morphogenesis Ventricular Septum Morphogenesis Regulation Of Negative Chemotaxis Negative Chemotaxis Roundabout Binding Response To Cortisol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Heart Valve Morphogenesis Regulation Of Cytokine-mediated Signaling Pathway Cardiac Septum Morphogenesis Axon Extension Involved In Axon Guidance Neuron Projection Guidance Axon Guidance Endothelial Cell Migration Pulmonary Valve Morphogenesis Chemotaxis Locomotion Regulation Of G Protein-coupled Receptor Signaling Pathway Apoptotic Process Involved In Development Regulation Of Macroautophagy Positive Regulation Of Secretion Of Lysosomal Enzymes Histone H2AS1 Kinase Activity Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Axon Extension Signal Transduction Negative Regulation Of Chemotaxis Transport Vesicle Membrane Nuclear Receptor Activity Neuron Projection Development Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Histone H3S28 Kinase Activity Negative Regulation Of Retinal Ganglion Cell Axon Guidance Aldehyde Dehydrogenase (NADP+) Activity 11-cis-retinol Dehydrogenase (NADP+) Activity Nuclear Proteasome Complex Protein Localization To Secretory Granule Negative Regulation Of Negative Chemotaxis Positive Regulation Of Axonogenesis
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