TH and NPAS1

		TH	NPAS1
Description		tyrosine hydroxylase	neuronal PAS domain protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Axon Cytoplasmic Vesicle Melanosome Membrane Cell Projection Neuron Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm	Chromatin Nucleus
	Molecular Function	Monooxygenase Activity Tyrosine 3-monooxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Enzyme Binding Identical Protein Binding Metal Ion Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Response To Hypoxia Synaptic Transmission, Dopaminergic Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Heart Development Visual Perception Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Aromatic Amino Acid Metabolic Process Anatomical Structure Morphogenesis Animal Organ Morphogenesis Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Serotonin Biosynthetic Process Eye Photoreceptor Cell Development Eating Behavior Pigmentation Response To Ethanol Embryonic Camera-type Eye Morphogenesis Cognition Hyaloid Vascular Plexus Regression	Negative Regulation Of Transcription By RNA Polymerase II Startle Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Maternal Behavior Negative Regulation Of DNA-templated Transcription
Pathways		Catecholamine biosynthesis
Drugs		Phenylalanine Tyrosine Sapropterin Metyrosine 3-Tyrosine L-erythro-7,8-dihydrobiopterin
Diseases		Primary torsion dystonia (PTD)
GWAS		Celiac disease ( 23936387) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iron status biomarkers (ferritin levels) ( 33536631) Prostate cancer ( 19767753) Prostate cancer (early onset) ( 24740154) Prostate cancer (SNP x SNP interaction) ( 22219177) Severe autoimmune type 2 diabetes ( 34737425) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 25102180 31324766)	Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee or tea ( 33287642)
Interacting Genes		31 interacting genes: CAMK2G CDK11B CRABP1 CSNK2A1 DAAM2 GAD1 HLA-G HNRNPK MAPK1 MAPK3 MAPKAPK2 MDFI NPAS1 PHLDA2 PIAS2 PRKACA PUF60 RBMY1A1 RNH1 RPS6KA5 SHC1 SNCA STIM1 TNNI2 TRIM21 TSPYL4 TYSND1 UMAD1 YWHAB YWHAZ ZNF569	1 interacting genes: TH
Entrez ID		7054	4861
HPRD ID		01865	09136
Ensembl ID		ENSG00000180176	ENSG00000130751
Uniprot IDs		P07101 P78428	Q99742
PDB IDs		2XSN 4J6S 6ZN2 6ZVP 6ZZU 7A2G 7PIM
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Serine Kinase Activity Regulation Of Primary Metabolic Process Protein Serine/threonine Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Kinase Activity TORC1 Signaling Interleukin-34-mediated Signaling Pathway Kinase Activity Negative Regulation Of Macromolecule Metabolic Process TOR Signaling Regulation Of Golgi Inheritance Negative Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Protein Phosphorylation Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of Protein Stability Phosphoserine Residue Binding Protein Domain Specific Binding Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Multicellular Organismal Process Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Regulation Of Signal Transduction Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Regulation Of MRNA Processing Focal Adhesion Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Long-term Synaptic Potentiation Nucleus ERK1 And ERK2 Cascade Bergmann Glial Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Epinephrine Stimulus	Tyrosine 3-monooxygenase Activity Dopamine Biosynthetic Process From Tyrosine Serotonin Biosynthetic Process Epinephrine Biosynthetic Process Epinephrine Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Hyaloid Vascular Plexus Regression Norepinephrine Biosynthetic Process Dopamine Biosynthetic Process Synaptic Transmission, Dopaminergic Serotonin Metabolic Process Anatomical Structure Regression Norepinephrine Metabolic Process Embryonic Camera-type Eye Morphogenesis Tyrosine Metabolic Process Catecholamine Biosynthetic Process Smooth Endoplasmic Reticulum Mating Behavior Melanosome Membrane Embryonic Eye Morphogenesis Amine Biosynthetic Process Eating Behavior Eye Photoreceptor Cell Development Biogenic Amine Biosynthetic Process Reproductive Behavior Dopamine Metabolic Process Photoreceptor Cell Development Aromatic Amino Acid Metabolic Process Catecholamine Metabolic Process Pigmentation Heart Morphogenesis Eye Morphogenesis Monooxygenase Activity Biogenic Amine Metabolic Process Sensory Organ Morphogenesis Amine Metabolic Process Phenol-containing Compound Metabolic Process Feeding Behavior Cytoplasmic Side Of Plasma Membrane Iron Ion Binding Response To Ethanol Memory Embryonic Organ Morphogenesis Synaptic Vesicle Perikaryon Learning L-amino Acid Metabolic Process Neuron Development Visual Perception Locomotory Behavior
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