ACTC1 and KLHL2

Number of citations of the paper that reports this interaction (PubMedID 10397770)
53

Data Source:
BioGRID (far western blotting)

		ACTC1	KLHL2
Description		actin alpha cardiac muscle 1	kelch like family member 2
Image
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Synapse Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity Myosin Binding	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Actin Filament Organization Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Actin Filament-based Movement Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Cytoplasmic Actin-based Contraction Involved In Cell Motility Mesenchyme Migration	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Striated Muscle Contraction RHOA GTPase cycle RHOB GTPase cycle Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM) Atrial septal defect
GWAS		Axial length ( 24144296) Refractive error ( 20835239 32231278)	Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		43 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 LINC00624 MIB2 MPC1 MYLK OGT PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	30 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA FRAS1 KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114
Entrez ID		70	11275
HPRD ID		00015	09311
Ensembl ID		ENSG00000159251	ENSG00000109466
Uniprot IDs		B3KPP5 P68032	B4DFZ5 E9PEX9 O95198
PDB IDs		8GSU 8GSW 8GT1 8GT2 8GT3 8GT4 8GT5 8ZB7 8ZI9 8ZJ1 9B3Q 9B3R	2XN4 4CHB
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Cytoskeleton Actin Filament Binding Cytoskeleton Actin Filament-based Process Actin Filament Organization Cytoplasm Focal Adhesion Regulation Of Lamellipodium Assembly Actin Filament Supramolecular Fiber Organization Regulation Of Lamellipodium Organization Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Myofibril Cell Projection Assembly Lamellipodium Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Regulation Of Cell Projection Organization Cortical Cytoskeleton Z Disc Postsynaptic Actin Cytoskeleton Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Cell Projection Assembly Filopodium Regulation Of Actin Cytoskeleton Organization Stress Fiber Plasma Membrane Bounded Cell Projection Assembly Negative Regulation Of Actin Filament Depolymerization Regulation Of Cellular Component Size Regulation Of Actin Filament-based Process Cell Projection Regulation Of Actin Filament Depolymerization Regulation Of Protein-containing Complex Assembly Brush Border Regulation Of Actin Filament Polymerization Actin Filament-based Movement Extracellular Exosome Cytosol Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Lamellipodium Assembly Negative Regulation Of Protein-containing Complex Disassembly Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament Organization Cell Projection Organization	Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis
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