HSPA13 and DNM1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HSPA13	DNM1
Description		heat shock protein family A (Hsp70) member 13	dynamin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytoplasm Microtubule Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Cytoplasmic Vesicle Chromaffin Granule Cell Projection Synapse Extracellular Exosome Presynapse
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Hydrolase Activity GDP Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Folding Protein Refolding	Endocytosis Receptor-mediated Endocytosis Endosome Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Homooligomerization Protein Homotetramerization Regulation Of Vesicle Size Clathrin Coat Assembly Involved In Endocytosis Vesicle Scission
Pathways		Regulation of HSF1-mediated heat shock response	Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Clathrin-mediated endocytosis
Drugs		Copper
Diseases
GWAS			Attention deficit hyperactivity disorder ( 18839057) Body mass index ( 26426971) Coenzyme Q10 levels ( 27149984) Platelet distribution width ( 32888494)
Interacting Genes		43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT	54 interacting genes: AMPH AP2A2 ASB13 BIN1 CABIN1 CAV1 CDK5 CEP126 CLIC3 CLIC4 CLINT1 CTTN DNMBP DYRK1A EPS15 FILNC1 FNBP1 FTCD GRB2 GRIN1 GRIN2D HSPA13 ITSN1 MAP3K10 MED31 MOB4 NCK1 NCK2 NME2 PACSIN1 PACSIN2 PACSIN3 PCNT PFN2 PIAS1 PIK3R1 PIN4 PLCG1 PLK2 PRKCA PRNP RACK1 RNF10 SH3GL1 SH3GL2 SH3GL3 SHANK2 SNAP25 SNCA SNX9 SRC SUMO1 TIMM50 UBE2I
Entrez ID		6782	1759
HPRD ID		03061	03851
Ensembl ID		ENSG00000155304	ENSG00000106976
Uniprot IDs		A0A140VK72 P48723	A0A994J7J4 B4DK06 B7ZAC0 Q05193
PDB IDs			1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 3ZYS 4UUD 4UUK 5D3Q 6DLU 6DLV 6S9A 7AX3 8SXZ 8SZ4 8SZ7 8SZ8 8T0K 8T0R 8TYM 8TYN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process	Endocytosis Import Into Cell Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse Presynaptic Endocytosis Glutamatergic Synapse Cytoplasm Lipid Binding Positive Regulation Of Protein-containing Complex Assembly Regulation Of Transport Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Positive Regulation Of Actin Filament Polymerization Regulation Of Endocytosis Positive Regulation Of Cellular Component Biogenesis Cytosol Regulation Of Biological Quality Regulation Of Cellular Component Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Polymerization Perinuclear Region Of Cytoplasm Presynapse Cellular Component Assembly Receptor-mediated Endocytosis Negative Regulation Of Endocytosis Plasma Membrane Plasma Membrane Tubulation Clathrin-coated Pit Phospholipid Binding Regulation Of Actin Filament Polymerization Negative Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Regulation Of Synaptic Plasticity Cytoskeleton Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Modulation Of Chemical Synaptic Transmission Regulation Of Actin Filament Length Regulation Of Calcium Ion Transmembrane Transport Regulation Of Protein Metabolic Process Regulation Of Calcium Ion Transport Cadherin Binding Neurotrophin TRKA Receptor Binding Regulation Of Cytoskeleton Organization Synapse Negative Regulation Of Transport Long-term Synaptic Potentiation Regulation Of Signaling Regulation Of Apoptotic Process
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