HSPA13 and TLN2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		HSPA13	TLN2
Description		heat shock protein family A (Hsp70) member 13	talin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome	Ruffle Cytoplasm Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Synapse Anchoring Junction Presynapse
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Heat Shock Protein Binding Protein Folding Chaperone ATP-dependent Protein Folding Chaperone	Actin Binding Integrin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Protein Folding Protein Refolding	Cell-cell Junction Assembly Cell Adhesion Actin Cytoskeleton Organization Cell-cell Adhesion Presynaptic Actin Cytoskeleton Organization
Pathways		Regulation of HSF1-mediated heat shock response
Drugs		Copper
Diseases
GWAS			A body shape index ( 34021172) Appendicular lean mass ( 33097823) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Periventricular white matter hyperintensities ( 32517579) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		43 interacting genes: AHCY APP ARHGAP5 BAG6 CAMLG CAND1 CHMP3 CKAP5 CLU CRYGA CTNNA1 DHX30 DHX35 DNM1 DNM3 FRY GIT1 HSP90B1 HSPH1 KIAA0319L LRBA MVP OGT PCBP1 PLXNB3 POLE4 PPP4R3B PSAP PTGES2 PTK2 RALBP1 RMI1 SGTA SGTB SSR1 ST18 TLN2 UBQLN1 UBQLN2 UBQLN4 UBR4 WDR3 XPOT	3 interacting genes: CLK1 HSPA13 PIP5K1C
Entrez ID		6782	83660
HPRD ID		03061	09555
Ensembl ID		ENSG00000155304	ENSG00000171914
Uniprot IDs		A0A140VK72 P48723	Q9Y4G6
PDB IDs			6U4K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of ERAD Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cellular Component Assembly Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Polyubiquitin Modification-dependent Protein Binding ERAD Pathway TRC Complex Positive Regulation Of Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Proteasomal Protein Catabolic Process Protein Targeting Positive Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Membrane Low-density Lipoprotein Particle Receptor Binding Chromaffin Granule Localization Within Membrane Perinuclear Region Of Cytoplasm Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Regulation Of Protein Metabolic Process Cellular Localization Protein Insertion Into ER Membrane Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Targeting To ER Identical Protein Binding Cytosol Establishment Of Protein Localization To Endoplasmic Reticulum Protein Phosphatase Binding Autophagy Cytoplasm Positive Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Membrane Positive Regulation Of Microtubule Nucleation Cytoskeleton Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Manganese Ion Establishment Of Protein Localization Negative Regulation Of Protein Catabolic Process
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