DNM1 and PLK2

Number of citations of the paper that reports this interaction (PubMedID 20802490)
50

Data Source:
BioGRID (pull down)

		DNM1	PLK2
Description		dynamin 1	polo like kinase 2
Image
GO Annotations	Cellular Component	Cytoplasm Microtubule Plasma Membrane Clathrin-coated Pit Membrane Endocytic Vesicle Cytoplasmic Vesicle Chromaffin Granule Cell Projection Synapse Extracellular Exosome Presynapse	Kinetochore Chromatin Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Dendrite Cell Projection
	Molecular Function	Nucleotide Binding RNA Binding GTPase Activity Protein Binding GTP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Hydrolase Activity GDP Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity ATP-dependent Protein Binding Protein Serine Kinase Activity
	Biological Process	Endocytosis Receptor-mediated Endocytosis Endosome Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Protein Homooligomerization Protein Homotetramerization Regulation Of Vesicle Size Clathrin Coat Assembly Involved In Endocytosis Vesicle Scission	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Mitotic Spindle Organization Ras Protein Signal Transduction Memory Positive Regulation Of Autophagy Regulation Of Cell Cycle Process Negative Regulation Of Angiogenesis DNA Damage Response, Signal Transduction By P53 Class Mediator Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long-term Synaptic Depression Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Senescence
Pathways		Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Clathrin-mediated endocytosis	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CD163 mediating an anti-inflammatory response NPAS4 regulates expression of target genes
Drugs			Fostamatinib
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Body mass index ( 26426971) Coenzyme Q10 levels ( 27149984) Platelet distribution width ( 32888494)	Blond vs. brown/black hair color ( 30531825) Diastolic blood pressure ( 30224653) Esophageal adenocarcinoma x smoking interaction ( 29551738) Multisite chronic pain ( 33830993) Triglyceride levels ( 32203549) Type 2 diabetes (age of onset) ( 28060188) Working memory ( 31598132)
Interacting Genes		54 interacting genes: AMPH AP2A2 ASB13 BIN1 CABIN1 CAV1 CDK5 CEP126 CLIC3 CLIC4 CLINT1 CTTN DNMBP DYRK1A EPS15 FILNC1 FNBP1 FTCD GRB2 GRIN1 GRIN2D HSPA13 ITSN1 MAP3K10 MED31 MOB4 NCK1 NCK2 NME2 PACSIN1 PACSIN2 PACSIN3 PCNT PFN2 PIAS1 PIK3R1 PIN4 PLCG1 PLK2 PRKCA PRNP RACK1 RNF10 SH3GL1 SH3GL2 SH3GL3 SHANK2 SNAP25 SNCA SNX9 SRC SUMO1 TIMM50 UBE2I	16 interacting genes: AP1B1 AP1G1 AP2A1 APP CASK CDC20B CENPU CIB1 DNM1 MPP3 NEDD4 NRIP1 NSF TSC1 TSC2 TUBA1A
Entrez ID		1759	10769
HPRD ID		03851	06118
Ensembl ID		ENSG00000106976	ENSG00000145632
Uniprot IDs		A0A994J7J4 B4DK06 B7ZAC0 Q05193	A0A087WUH9 Q9NYY3
PDB IDs		1DYN 2DYN 2X2E 2X2F 3SNH 3ZYC 3ZYS 4UUD 4UUK 5D3Q 6DLU 6DLV 6S9A 7AX3 8SXZ 8SZ4 8SZ7 8SZ8 8T0K 8T0R 8TYM 8TYN	4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Synaptic Vesicle Endocytosis Vesicle-mediated Transport In Synapse Presynaptic Endocytosis Glutamatergic Synapse Cytoplasm Lipid Binding Positive Regulation Of Protein-containing Complex Assembly Regulation Of Transport Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Positive Regulation Of Actin Filament Polymerization Regulation Of Endocytosis Positive Regulation Of Cellular Component Biogenesis Cytosol Regulation Of Biological Quality Regulation Of Cellular Component Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Polymerization Perinuclear Region Of Cytoplasm Presynapse Cellular Component Assembly Receptor-mediated Endocytosis Negative Regulation Of Endocytosis Plasma Membrane Plasma Membrane Tubulation Clathrin-coated Pit Phospholipid Binding Regulation Of Actin Filament Polymerization Negative Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Regulation Of Synaptic Plasticity Cytoskeleton Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Modulation Of Chemical Synaptic Transmission Regulation Of Actin Filament Length Regulation Of Calcium Ion Transmembrane Transport Regulation Of Protein Metabolic Process Regulation Of Calcium Ion Transport Cadherin Binding Neurotrophin TRKA Receptor Binding Regulation Of Cytoskeleton Organization Synapse Negative Regulation Of Transport Long-term Synaptic Potentiation Regulation Of Signaling Regulation Of Apoptotic Process	Clathrin-coated Pit Intracellular Protein Transport Endocytosis Membrane Coat Establishment Of Localization In Cell TSC1-TSC2 Complex Vesicle-mediated Transport Intracellular Transport Regulation Of Vesicle-mediated Transport Basolateral Protein Secretion Import Into Cell Lysosomal Membrane Cellular Localization Protein Transport Perinuclear Region Of Cytoplasm Positive Regulation Of Protein Catabolic Process Clathrin Adaptor Complex AP-1 Adaptor Complex Adult Locomotory Behavior Positive Regulation Of Protein Metabolic Process Intracellular Protein Localization Synapse Organization Establishment Of Protein Localization Associative Learning Golgi Apparatus Filopodium Tip Clathrin Adaptor Activity Post-Golgi Vesicle-mediated Transport Melanosome Assembly Synapse Positive Regulation Of Catabolic Process Trans-Golgi Network Membrane Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell-matrix Adhesion Platelet Dense Granule Organization Low-density Lipoprotein Particle Receptor Binding Recycling Endosome Regulation Of Transport Regulation Of Protein Catabolic Process Adult Behavior Ionotropic Glutamate Receptor Binding Negative Regulation Of Cell Population Proliferation Learning Cytosol Vesicle Budding From Membrane Clathrin-coated Vesicle Membrane Receptor-mediated Endocytosis Melanosome Organization Negative Regulation Of Macroautophagy Pigment Granule Organization
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